An increasing number of patients suffering from type 2 diabetes are offered a pharmaceutical preparation called Exenatide, which helps them to control their blood sugar. The drug is a synthetic version of a natural substance called exendin-4, which is obtained from a rather unusual source – the saliva of the Gila monster lizard (Heloderma suspectum), North America’s largest lizard.
“This is both unknown and quite unexpected effect,” comments an enthusiastic Karolina Skibicka:
“ Our decision to eat is linked to the same mechanisms in the brain which control addictive behaviours. We have shown that exendin-4 affects the reward and motivation regions of the brain”Significant findings
“Most dieting fails because we are obsessed with the desire to eat, especially tempting foods like sweets. As exendin-4 suppresses the cravings for food, it can help obese people to take control of their weight,” suggests Professor Dickson.
The article “The Glucagon-Like Peptide 1 (GLP-1) Analogue, Exendin-4 Decreases the Rewarding Value of Food: A New Role for the Mesolimbic GLP-1 Receptors” was published in the Journal of Neuroscience, in the April 4 issue.For further information please contact:
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