Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Disturbances in certain genes play a role in autism

16.08.2010
Together with colleagues from an international research group, autism researcher Christopher Gillberg of the University of Gothenburg, Sweden, has found in a new study that autism can be partially explained by abnormalities in certain genes. The group’s results could, in the long run, pave the way for more appropriate treatments for autism.

Prestigious journal Nature is publishing an article co-authored by Christopher Gillberg of the Unit for Child and Adolescent Psychiatry at the Institute of Neuroscience and Physiology, and member of the Autism Genome Project (AGP) research group.

In the article the group reveals that a survey of 1,000 individuals with autism and 1,300 without showed that Copy Number Variants (CNVs) – sub-microscopic abnormalities in the chromosomes – are heavily over-represented in autistic people.

“Some of these are inherited, while others have appeared for the first time in the person with autism,” says Gillberg. “Several of the abnormalities affect the genes that we have previously shown to be linked to autism and psychological developmental disorders”.

The article stresses something that Gillberg and his colleagues have long asserted, namely that autism is partly down to a number of completely different genetic abnormalities, each of which occurs in just a small number of autistic people, but which together account for an increasing proportion of all cases, and that autism is an umbrella term for a large number of different neurobiological conditions that have the same symptom picture.

The study also provides evidence that other genes that are important for synapse development and intra-cellular communication (communication between the nerve cells) play a role in the origin of autism in some cases. It is hoped that the link with synapse development and intra-cellular communication will pave the way for more appropriate treatment in the long term.

“Only when we know what is actually causing the autism in each case can we customise a treatment involving medication and diet,” says Gillberg.

Gillberg is also one of the initiative-takers behind AGP, a group of 120 scientists from 11 different countries who have joined forces to identify the genetic factors underlying autism. He and his colleagues in the group also published, in Nature in 2003, 2007 and 2009, the first studies to show that the mutated genes that affect the early development of synapses also cause autism in some cases.

AUTISM
Around one in 100 children has autism and it is more common in boys than girls. Typical symptoms are major difficulties with social interaction and rigid, stereotypical behaviour starting before the age of three.
For more information, please contact:
Christopher Gillberg, professor, tel. +46 31 342 5970, e-mail: christopher.gillberg@pediat.gu.se
Journal: Nature
Title of article: Functional impact of global rare copy number variation in autism spectrum disorder

Authors: Et al Christopher Gillberg

Helena Aaberg | idw
Further information:
http://www.nature.com/nature/journal/v466/n7304/full/nature09146.html
http://www.gu.se

More articles from Life Sciences:

nachricht Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>