The molecule, known as Lysyl-tRNA synthetase (or LysRS in brief) is one of the most ancient molecules in the cell, where it has long been recognized for its contribution in the translation of the information contained in RNA into the amino acids that make up proteins. Amino acids are organic compounds which are present in and vital to every living cell.
Now, the Hebrew University scientists have discovered that LysRS plays an important additional role as a central regulator controlling expression of various genes. In this additional role, LysRS ceases its previous function at a certain point and participates in a chain of events that causes the freeing of inhibitors that prevent expression of certain genes.
The researchers say that this research has particularly great importance, since LysRS is known to be involved in diseases such as AIDS and cancers. The virus HIV uses the host's cellular LysRS in the process of replication. High levels of LysRS also have been observed in certain cancers, such as breast cancer. The specific molecular mechanisms in these contexts remain to be discovered.
An ability to understand the regulatory effect played by LysRS in various diseases could make an important contribution to the worldwide search for therapies that would control the “turning on” or “turning off” of specific genes that are operative in those diseases, they emphasize.
This research was performed by doctoral students Nurit Yannay-Cohen and Irit Carmi-Levy within the Department of Biochemistry and Molecular Biology, the Institute for Medical Research - Israel-Canada, at the Hebrew University Faculty of Medicine. The research was done under the guidance of Prof. Ehud Razin, former dean of the faculty, and Dr. Hovav Nechushtan. Their work was published in the journal Molecular Cell.
Jerry Barach | Hebrew University
Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München
Second research flight into zero gravity
21.10.2016 | Universität Zürich
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences