Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Discovery of regulatory role of key molecule provides further step towards future gene therapy to control disease

16.09.2009
Discovery by Hebrew University of Jerusalem researchers of an additional role for a key molecule in our bodies provides a further step in world-wide efforts to develop genetic regulation aimed at controlling many diseases, including AIDS and various types of cancers.

The molecule, known as Lysyl-tRNA synthetase (or LysRS in brief) is one of the most ancient molecules in the cell, where it has long been recognized for its contribution in the translation of the information contained in RNA into the amino acids that make up proteins. Amino acids are organic compounds which are present in and vital to every living cell.

Now, the Hebrew University scientists have discovered that LysRS plays an important additional role as a central regulator controlling expression of various genes. In this additional role, LysRS ceases its previous function at a certain point and participates in a chain of events that causes the freeing of inhibitors that prevent expression of certain genes.

The researchers say that this research has particularly great importance, since LysRS is known to be involved in diseases such as AIDS and cancers. The virus HIV uses the host's cellular LysRS in the process of replication. High levels of LysRS also have been observed in certain cancers, such as breast cancer. The specific molecular mechanisms in these contexts remain to be discovered.

An ability to understand the regulatory effect played by LysRS in various diseases could make an important contribution to the worldwide search for therapies that would control the “turning on” or “turning off” of specific genes that are operative in those diseases, they emphasize.

This research was performed by doctoral students Nurit Yannay-Cohen and Irit Carmi-Levy within the Department of Biochemistry and Molecular Biology, the Institute for Medical Research - Israel-Canada, at the Hebrew University Faculty of Medicine. The research was done under the guidance of Prof. Ehud Razin, former dean of the faculty, and Dr. Hovav Nechushtan. Their work was published in the journal Molecular Cell.

Jerry Barach | Hebrew University
Further information:
http://www.huji.ac.il

More articles from Life Sciences:

nachricht More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>