Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Discovery of “probiotic transporters” unlocks secrets of infection-preventive bifidobacteria

27.01.2011
Researchers at RIKEN, Yokohama City University and the University of Tokyo have uncovered how gut bifidobacteria protect the body against lethal infection by enhancing the defenses of colonic epithelium.

Published in this week’s issue of Nature, the finding provides first-ever clues on the mechanisms underlying the beneficial effects of gut microbiota, promising more effective probiotic therapies for a variety of disorders and diseases.

In recent years, new metagenomics techniques have enabled scientists to delve ever-deeper into the world of gut microbiota, revealing the strong influence that intestinal bacteria exert on our health. Bifidobacteria, one of the most numerous such bacteria, confer to their hosts a range of beneficial health effects, aiding in digestion, boosting the immune system and even reducing cancer risk. The mechanism underlying these effects, however, has remained a mystery.

With their study, the research team set out to unravel this mystery using a combination of techniques from genetics, transcriptomics and metabolomics. Initial experiments on so-called germ-free (GF) mice, whose guts are uncolonized by bacteria, revealed stark differences between bifidobacteria strains. The researchers found that mice colonized by one bifidobacterium subspecies, B. longum, were able to survive when fed the pathogenic bacteria E. coli O157, while GF mice without the bacteria died of infection within 7 days. Another strain named B. adolescentis, in contrast, had no such effect.

By analyzing fecal metabolic profiles, the researchers succeeded in pinpointing the source of this difference in the production of acetate, which they showed enhances intestinal epithelial defense and protects against infection from O157. The key actor in this mechanism is a carbohydrate transporter encoded by genes present in certain strains of bifidobacteria such as B. longum, which enables these bacteria to utilize fructose to produce acetate in the distal colon.

As a demonstration of the power of multi “omics” technologies, the identification of these “probiotic transporters” constitutes a milestone in the study of gut microbiota. The finding also demonstrates the power of multi “omics” technologies for analyzing the gut ecosystem, promising advancements in the development of cutting-edge probiotic therapies.

For more information, please contact:

Dr. Ohno Hiroshi
Laboratory for Epithelial Immunobiology
RIKEN Research Center for Allergy and Immunology
Tel: +81-(0)45-503-7031 / Fax: +81-(0)45-503-7068
Ms. Tomoko Ikawa (PI officer)
Global Relations Office
RIKEN
Tel: +81-(0)48-462-1225 / Fax: +81-(0)48-463-3687
Email: koho(at)riken.jp
Reference:
Shinji Fukuda, Hidehiro Toh, Koji Hase, Kenshiro Oshima, Yumiko Nakanishi, Kazutoshi Yoshimura, Toru Tobe, Julie M. Clarke, David L. Topping, Tohru Suzuki, Todd D. Taylor, Kikuji Itoh, Jun Kikuchi, Hidetoshi Morita, Masahira Hattori and Hiroshi Ohno. Bifidobacteria protect host from enteropathogenic infection through production of acetate. Nature (2010). DOI: 10.1038/nature09646

Robin Bisson | Research asia research news
Further information:
http://www.riken.jp
http://www.researchsea.com

More articles from Life Sciences:

nachricht Molecular microscopy illuminates molecular motor motion
26.07.2017 | Penn State

nachricht New virus discovered in migratory bird in Rio Grande do Sul, Brazil
26.07.2017 | Fundação de Amparo à Pesquisa do Estado de São Paulo

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Carbon Nanotubes Turn Electrical Current into Light-emitting Quasi-particles

Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers

Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...

Im Focus: Flexible proximity sensor creates smart surfaces

Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.

At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

 
Latest News

CCNY physicists master unexplored electron property

26.07.2017 | Physics and Astronomy

Molecular microscopy illuminates molecular motor motion

26.07.2017 | Life Sciences

Large-Mouthed Fish Was Top Predator After Mass Extinction

26.07.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>