BASF and University of Göttingen scientists find new specific insecticide target protein
Scientists from BASF Crop Protection and the University of Göttingen in Germany have found a new insecticide target protein. The discovery marks the first identification of vanilloid receptors, the TRPV ion channels, as insecticide targets. The results were published in the scientific journal Neuron. They could help to better manage insecticide resistance and have implications for research and insecticide usage.
In their study, the scientists focused on the mode of action of the insecticides pymetrozine and pyrifluquinanzon. They identified a novel TRPV ion channel complex as the target protein of the two chemicals.
In insects, two TRPV channels exist, which occur together in certain stretch receptors that are present in joints, for example in the antennae and legs. By sensing mechanical stimuli, these stretch receptors provide insects with their senses of balance, hearing and coordination.
The two insecticides only act selectively on these stretch receptors because they activate an ion channel complex formed by the two TRPV channels. By activating this TRPV channel complex, the insecticides overstimulate the stretch receptors, disturbing insect locomotion and feeding. Substances with this mode of action are effective against many plant-sucking pests, particularly whiteflies and aphids.
By knowing the exact target of pymetrozine and pyrifluquinanzon, the industry can now provide better advice on spray programs to farmers. „For instance, we would not want to treat fields with these two substances one after the other. The more you attack one particluar site, the faster insects will become resistant. The findings help us to use insecticides more wisely and more sustainably,“ says Dr. Vincent Salgado, biologist at BASF Crop Protection.
„The fact that the two insecticides target a TRPV channel complex is particularly interesting,“ says the Göttingen neuroscientist Prof. Dr. Martin Göpfert. „For a long time we thought that the two insect TRPVs might form a complex in those stretch receptors, but only the insecticides allowed us to show that this is what they do.“
The study thus encompasses exciting biology: It identifies a novel ion channel complex that plays a key role in the detection of mechanical stimuli. Furthermore, the methods employed by the study can be applied to other insecticides, and they may help in the identification of new insecticides with similar modes of action.
Original publication: Alexandre Nesterov et al. TRP Channels in Insect Stretch Receptors as Insecticide Targets. Neuron 2015. Doi: 10.1016/j.neuron.2015.04.001.
Prof. Dr. Martin Göpfert
University of Göttingen – Department of Cellular Neurobiology
Julia-Lermontowa-Weg 3, 37077 Göttingen
Phone +49 551 39-177955
BASF SE Crop protection
Phone +49 621 60-28182
Prof. Dr. Martin Göpfert | idw - Informationsdienst Wissenschaft
Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside
Chlamydia: How bacteria take over control
28.03.2017 | Julius-Maximilians-Universität Würzburg
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
28.03.2017 | Physics and Astronomy
28.03.2017 | Health and Medicine
28.03.2017 | Life Sciences