BASF and University of Göttingen scientists find new specific insecticide target protein
Scientists from BASF Crop Protection and the University of Göttingen in Germany have found a new insecticide target protein. The discovery marks the first identification of vanilloid receptors, the TRPV ion channels, as insecticide targets. The results were published in the scientific journal Neuron. They could help to better manage insecticide resistance and have implications for research and insecticide usage.
In their study, the scientists focused on the mode of action of the insecticides pymetrozine and pyrifluquinanzon. They identified a novel TRPV ion channel complex as the target protein of the two chemicals.
In insects, two TRPV channels exist, which occur together in certain stretch receptors that are present in joints, for example in the antennae and legs. By sensing mechanical stimuli, these stretch receptors provide insects with their senses of balance, hearing and coordination.
The two insecticides only act selectively on these stretch receptors because they activate an ion channel complex formed by the two TRPV channels. By activating this TRPV channel complex, the insecticides overstimulate the stretch receptors, disturbing insect locomotion and feeding. Substances with this mode of action are effective against many plant-sucking pests, particularly whiteflies and aphids.
By knowing the exact target of pymetrozine and pyrifluquinanzon, the industry can now provide better advice on spray programs to farmers. „For instance, we would not want to treat fields with these two substances one after the other. The more you attack one particluar site, the faster insects will become resistant. The findings help us to use insecticides more wisely and more sustainably,“ says Dr. Vincent Salgado, biologist at BASF Crop Protection.
„The fact that the two insecticides target a TRPV channel complex is particularly interesting,“ says the Göttingen neuroscientist Prof. Dr. Martin Göpfert. „For a long time we thought that the two insect TRPVs might form a complex in those stretch receptors, but only the insecticides allowed us to show that this is what they do.“
The study thus encompasses exciting biology: It identifies a novel ion channel complex that plays a key role in the detection of mechanical stimuli. Furthermore, the methods employed by the study can be applied to other insecticides, and they may help in the identification of new insecticides with similar modes of action.
Original publication: Alexandre Nesterov et al. TRP Channels in Insect Stretch Receptors as Insecticide Targets. Neuron 2015. Doi: 10.1016/j.neuron.2015.04.001.
Prof. Dr. Martin Göpfert
University of Göttingen – Department of Cellular Neurobiology
Julia-Lermontowa-Weg 3, 37077 Göttingen
Phone +49 551 39-177955
BASF SE Crop protection
Phone +49 621 60-28182
Prof. Dr. Martin Göpfert | idw - Informationsdienst Wissenschaft
Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
22.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
18.05.2018 | Power and Electrical Engineering
18.05.2018 | Information Technology
18.05.2018 | Information Technology