Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Discovery increases understanding how bacteria spread: U of A study

21.06.2012
A University of Alberta researcher is moving closer to understanding how infection is caused by the spread of bacteria.
In a study published in the high-impact Cell Press journal called Structure, Joel Weiner and his collaborators, Gerd Prehna and Natalie Stynadka at the University of British Columbia, share new knowledge about how bacteria release proteins.

Proteins are complex molecules that perform all sorts of functions in the cells of living things. The group studied a specific protein called YebF in E. coli bacteria. It is widely found in other bacteria as well.

Solving the structure and understanding the mechanism by which this protein spreads bacterial pathogens was a big step forward. As humans develop more resistance to antibiotics, researchers are in search of new ways to stop bacteria from spreading.

"Most pathogenic bacteria induce special structures in order to release proteins that allow them to infect a host," said Weiner of the Department of Biochemistry, whose lab is funded by the Natural Sciences & Engineering Research Council and the Canadian Institutes of Health Research. "What we show here is that normal, run-of-the-mill bacteria can actually release a protein through the pores [of the bacterial membrane] which are normally there to take in small molecules."

YebF proved to be an interesting protein molecule because in addition to its release through the bacterial pore, which is the most recent discovery, it has the unique property of secreting "passenger proteins" that are attached to it. This unique property was a prior discovery patented by the U of A because it has potential use for the production of protein-based drugs by the pharmaceutical and biotechnology industry.

"What we found in the structure is that there are regions that are very flexible in YebF that seem to be very important in getting it out of the bacteria," said Weiner. "If you make mutants in those regions you can prevent the protein from going out.

"We're not investing enough in identifying new targets for antibiotics," he said. "What this system does suggests a new target. We're looking at drugs that could block the ability of YebF to go out.

"That's really easy to test for," he added. Because the screen is easy, it's good for pharmaceutical companies."

This step in the research took several years, because solving the structure of this protein wasn't easy. The lab typically uses crystallization but stubborn YebF wouldn't work, so instead they had to use nuclear magnetic resonance.

Typically researchers know what action takes place and they try to find the protein that triggers it. In this case the researchers have been working the opposite direction. They have the protein, YebF, but they need to find out its purpose in the cell.

Quinn Phillips | EurekAlert!
Further information:
http://www.ualberta.ca

More articles from Life Sciences:

nachricht Repairing damaged hearts with self-healing heart cells
22.08.2017 | National University Health System

nachricht Biochemical 'fingerprints' reveal diabetes progression
22.08.2017 | Umea University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Cholesterol-lowering drugs may fight infectious disease

22.08.2017 | Health and Medicine

Meter-sized single-crystal graphene growth becomes possible

22.08.2017 | Materials Sciences

Repairing damaged hearts with self-healing heart cells

22.08.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>