Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

“Dirty Dancing” with Maverick Chromosomes

15.12.2008
In his Newark laboratory, David Kaback, a professor of microbiology and molecular genetics at the UMDNJ-New Jersey Medical School, has captured the remarkable and never before seen undulations of “dancing chromosomes.”

The rhythm of life may beat far deeper than anyone previously thought. And it may gyrate and pulse in a way that rivals the sensuous choreography of “Dirty Dancing.”

In his Newark laboratory, David Kaback, a professor of microbiology and molecular genetics at the UMDNJ-New Jersey Medical School, has captured the remarkable and never before seen undulations of “dancing chromosomes,” and his discovery may lead to way to prevent conditions like Down, Turner and Klinefelter’s syndrome as well as lend insight into the causes of first trimester spontaneous miscarriages.

In lectures to researchers and medical and graduate students, Kaback refers to his discovery as “Dirty Dancing,” which he also calls the “Mating Rites of Homologous Chromosomes.” His work on the process of chromosome pairing has been published in the Proceedings of the National Academy of Sciences and the journal Genetics and is funded by the National Science Foundation and the National Institutes of Health.

Kaback’s research focuses on meiosis, the specific type of division that takes place in sperm and egg cells. When most cells divide, the result is two new cells, each with 23 pairs of chromosomes. But during meiosis, sperm and egg cells are left with just 23 single chromosomes. When a sperm and egg cell combine, the single chromosomes become pairs.

In his laboratory, Kaback attaches green fluorescent protein tags to the chromosomes in yeast cells, which undergo meiosis in a fashion similar to humans. With the fluorescent tags activated, Kaback and his colleague Harry Scherthan from the Max Planck Institute and Bundeswahr Institute of Radiobiology in Germany are able to capture video of these chromosomes as they moved in spectacular fashion, first seemingly searching for each other during the process of pairing. Once joined, the chromosome pairs continue to move rapidly around the cell nucleus, with some individual “maverick” chromosomes breaking out of the large pack of chromosomes, not unlike dancing lovers in an elaborately choreographed movie.

To request an interview with David Kaback, Ph.D., please contact Jerry Carey, UMDNJ News Service, at 973-972-3000.

The University of Medicine and Dentistry of New Jersey (UMDNJ) is the nation’s largest free-standing public health sciences university with more than 5,600 students attending the state's three medical schools, its only dental school, a graduate school of biomedical sciences, a school of health related professions, a school of nursing and a school of public health on five campuses.

Annually, there are more than two million patient visits at UMDNJ facilities and faculty practices at campuses in Newark, New Brunswick/Piscataway, Scotch Plains, Camden and Stratford. UMDNJ operates University Hospital, a Level I Trauma Center in Newark, and University Behavioral HealthCare, a statewide mental health and addiction services network.

Jerry Carey | Newswise Science News
Further information:
http://www.umdnj.edu

More articles from Life Sciences:

nachricht Antimicrobial substances identified in Komodo dragon blood
23.02.2017 | American Chemical Society

nachricht New Mechanisms of Gene Inactivation may prevent Aging and Cancer
23.02.2017 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

From rocks in Colorado, evidence of a 'chaotic solar system'

23.02.2017 | Physics and Astronomy

'Quartz' crystals at the Earth's core power its magnetic field

23.02.2017 | Earth Sciences

Antimicrobial substances identified in Komodo dragon blood

23.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>