Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

“Dirty Dancing” with Maverick Chromosomes

15.12.2008
In his Newark laboratory, David Kaback, a professor of microbiology and molecular genetics at the UMDNJ-New Jersey Medical School, has captured the remarkable and never before seen undulations of “dancing chromosomes.”

The rhythm of life may beat far deeper than anyone previously thought. And it may gyrate and pulse in a way that rivals the sensuous choreography of “Dirty Dancing.”

In his Newark laboratory, David Kaback, a professor of microbiology and molecular genetics at the UMDNJ-New Jersey Medical School, has captured the remarkable and never before seen undulations of “dancing chromosomes,” and his discovery may lead to way to prevent conditions like Down, Turner and Klinefelter’s syndrome as well as lend insight into the causes of first trimester spontaneous miscarriages.

In lectures to researchers and medical and graduate students, Kaback refers to his discovery as “Dirty Dancing,” which he also calls the “Mating Rites of Homologous Chromosomes.” His work on the process of chromosome pairing has been published in the Proceedings of the National Academy of Sciences and the journal Genetics and is funded by the National Science Foundation and the National Institutes of Health.

Kaback’s research focuses on meiosis, the specific type of division that takes place in sperm and egg cells. When most cells divide, the result is two new cells, each with 23 pairs of chromosomes. But during meiosis, sperm and egg cells are left with just 23 single chromosomes. When a sperm and egg cell combine, the single chromosomes become pairs.

In his laboratory, Kaback attaches green fluorescent protein tags to the chromosomes in yeast cells, which undergo meiosis in a fashion similar to humans. With the fluorescent tags activated, Kaback and his colleague Harry Scherthan from the Max Planck Institute and Bundeswahr Institute of Radiobiology in Germany are able to capture video of these chromosomes as they moved in spectacular fashion, first seemingly searching for each other during the process of pairing. Once joined, the chromosome pairs continue to move rapidly around the cell nucleus, with some individual “maverick” chromosomes breaking out of the large pack of chromosomes, not unlike dancing lovers in an elaborately choreographed movie.

To request an interview with David Kaback, Ph.D., please contact Jerry Carey, UMDNJ News Service, at 973-972-3000.

The University of Medicine and Dentistry of New Jersey (UMDNJ) is the nation’s largest free-standing public health sciences university with more than 5,600 students attending the state's three medical schools, its only dental school, a graduate school of biomedical sciences, a school of health related professions, a school of nursing and a school of public health on five campuses.

Annually, there are more than two million patient visits at UMDNJ facilities and faculty practices at campuses in Newark, New Brunswick/Piscataway, Scotch Plains, Camden and Stratford. UMDNJ operates University Hospital, a Level I Trauma Center in Newark, and University Behavioral HealthCare, a statewide mental health and addiction services network.

Jerry Carey | Newswise Science News
Further information:
http://www.umdnj.edu

More articles from Life Sciences:

nachricht Embryonic development: How do limbs develop from cells?
18.05.2018 | Humboldt-Universität zu Berlin

nachricht Reading histone modifications, an oncoprotein is modified in return
18.05.2018 | American Society for Biochemistry and Molecular Biology

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>