Are the eggs produced by adolescent girls the same as the ones produced by adult women?
A recent study published in Human Molecular Genetics by Professor Kui Liu from the University of Gothenburg in Sweden shows compelling evidence that there are two completely distinct types of eggs in the mammalian ovary – “the first wave” and “the adult wave”.
Different eggs in adolescent girls and adult women
Professor Liu’s team used two genetically modified mouse models to show that the first wave of eggs, which starts immediately after birth, contributes to the onset of puberty and provides fertilizable eggs into the transition from adolescence to adulthood.
In contrast, the adult wave remains in a state of dormancy until activated during the adult life and then provides eggs throughout the entire reproductive lifespan.
This is the first time that the developmental dynamics of two distinct populations of eggs have been clearly described in an animal model, and there is evidence that these two waves of eggs most likely also exist in the human ovary.
The identification and characterization of the two waves of eggs will lead to new ways of thinking about how to obtain the best eggs when treating women for ovarian diseases that cause infertility. Such techniques will prove especially useful for women suffering from premature ovarian failure (POF), which affects 1%–4% of all women of childbearing age.
The results may also lead to more effective treatments for ovarian diseases by specifically targeting the different egg populations.
Dr. Liu is a professor at the Department of Chemistry and Molecular Biology, University of Gothenburg. His research group specializes in the development of female germ cells. His work in recent years has focused on translating the results from animal models into clinical techniques for treating female infertility.
For more information, please contact Professor Kui Liu: Tel. +46 (0)073- 62 05 064; firstname.lastname@example.org
Carina Eliasson | idw - Informationsdienst Wissenschaft
The herbivore dilemma: How corn plants fights off simultaneous attacks
09.02.2016 | Boyce Thompson Institute for Plant Research
Shedding Light on Bacteria
09.02.2016 | Albert-Ludwigs-Universität Freiburg im Breisgau
Exceeding critical temperature limits in the Southern Ocean may cause the collapse of ice sheets and a sharp rise in sea levels
A future warming of the Southern Ocean caused by rising greenhouse gas concentrations in the atmosphere may severely disrupt the stability of the West...
Indications of light-induced lossless electricity transmission in fullerenes contribute to the search for superconducting materials for practical applications.
Superconductors have long been confined to niche applications, due to the fact that the highest temperature at which even the best of these materials becomes...
Researchers at King’s College London and the Wellcome Trust Sanger Institute in the United Kingdom have for the first time demonstrated a direct link between the Wbp2 gene and progressive hearing loss. The scientists report that the loss of Wbp2 expression leads to progressive high-frequency hearing loss in mouse as well as in two clinical cases of children with deafness with no other obvious features. The results are published in EMBO Molecular Medicine.
The scientists have shown that hearing impairment is linked to hormonal signalling rather than to hair cell degeneration. Wbp2 is known as a transcriptional...
Pollens, the bane of allergy sufferers, could represent a boon for battery makers: Recent research has suggested their potential use as anodes in lithium-ion batteries.
"Our findings have demonstrated that renewable pollens could produce carbon architectures for anode applications in energy storage devices," said Vilas Pol, an...
Automobiles increase the mobility of their users. However, their maneuverability is pushed to the limit by cramped inner city conditions. Those who need to...
09.02.2016 | Event News
02.02.2016 | Event News
26.01.2016 | Event News
09.02.2016 | Event News
09.02.2016 | Materials Sciences
09.02.2016 | Power and Electrical Engineering