Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Dialysis: Blood Protein as a Risk Factor

12.03.2013
A modified blood protein increases the mortality risk in patients undergoing dialysis treatment. This has been reported by researchers from Würzburg and Boston in the journal "Science Translational Medicine". They also have an idea about how the risk factor might be successfully dealt with.

Diabetes and high blood pressure can lead to impaired renal function and even to complete kidney failure in the end. This is a life-threatening situation for the people concerned.

They need to undergo dialysis treatment regularly, but the artificial blood filtration can only replace about 10 percent of normal renal function. Therefore, dialysis patients cannot consider themselves out of danger until they receive a kidney transplant. Due to the scarce supply of donor organs, however, not everyone is fortunate enough to get a transplant.

Why is it that kidney failure has such fatal consequences? The reason lies in the fact that the waste products, which should be excreted from the body via the urine, then accumulate in the blood. This increases the risk of additional conditions, such as atherosclerosis (formation of plaques in the arteries), heart attacks and strokes.

Harmless urea gives rise to the generation of toxic cyanate

In patients with kidney disease, one of the substances accumulating in the blood is urea, an originally harmless metabolic waste product. "However, urea can be converted in the body to a toxic cyanate, which binds to the blood proteins," explains Christiane Drechsler, a medical scientist at the Department of Nephrology of the University Hospital of Würzburg.

The dangerous cyanate also binds to albumin, which is one of the most important blood proteins. This has drastic consequences: The carbamylated albumin – as the modified albumin is known by scientists – now tends to stick to defective parts in the blood vessels. This aggravates the process of atherosclerosis, thus further reducing the survival chances of dialysis patients.

Amino acids can decrease the risk

"We have found a significant correlation: A higher amount of carbamylated albumin in the blood is associated with reduced survival chances of the respective patients," says Christiane Drechsler. The concentration of the dangerous albumin, in turn, increases with decreasing amino acid levels in the blood. This is because cysteine, histidine, lysine and some other amino acids are obviously able to inhibit the formation of the "high-risk albumin" – as has also been demonstrated by the Würzburg scientists and their colleagues from Boston (USA). The study evaluated data on 1,255 dialysis patients.

Pilot study with 200 patients planned

The results are published in the current issue of the journal "Science Translational Medicine". They open up the prospect of a new therapeutic approach that might be used to increase the life expectancy of kidney and dialysis patients: The administration of amino acids as a preventive measure. "We are now going to determine whether this method works in a pilot study currently in preparation, involving about 200 dialysis patients," says Professor Christoph Wanner, who heads the Department of Nephrology at the University Hospital of Würzburg.

The three main application possibilities yielded by the study

The study of the Würzburg and Boston researchers not only points to a new way of improving the survival rates of dialysis patients. It also provides two further benefits, as Christiane Drechsler explains: "The carbamylated albumin is a suitable candidate to serve as a prognostic marker in diagnostics. Furthermore, it might become a marker for assessing the quality of dialysis treatment over prolonged periods of time – similar to the HbA1c-test for diabetics."

"Carbamylation of Serum Albumin as a Risk Factor for Mortality in Patients with Kidney Failure", Anders H. Berg, Christiane Drechsler, Julia Wenger, Roberto Buccafusca, Tammy Hod, Sahir Kalim, Wenda Ramma, Samir M. Parikh, Hanno Steen, David J. Friedman, John Danziger, Christoph Wanner, Ravi Thadhani, S. Ananth Karumanchi. Science Translational Medicine, 6 March 2013, Vol. 5 Issue 175, p. 175ra29, DOI: 10.1126/scitranslmed.3005218

Contact person

Dr. Dr. Christiane Drechsler, Department of Internal Medicine I, University Hospital of Würzburg, T (0931) 201-39972, drechsler_c@klinik.uni-wuerzburg.de

Robert Emmerich | Uni Würzburg
Further information:
http://www.uni-wuerzburg.de

More articles from Life Sciences:

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

nachricht Research reveals how order first appears in liquid crystals
23.05.2018 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

A simple mechanism could have been decisive for the development of life

23.05.2018 | Life Sciences

Genetic diversity helps protect against disease

23.05.2018 | Life Sciences

Spinning rugby balls: The rotation of the most massive galaxies

23.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>