Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Development of a novel dual JAK/Src kinase inhibitor

07.01.2014
Inhibitors of both JAK and Src kinases represent promising targets for cancer therapeutics because of the central importance of these kinases in tumor cell proliferation and survival.

Furthermore, in cancer cells activation of JAK has been reported as a compensatory effect in response to Src inhibitor exposure. This implies simultaneous inhibition of both kinases could have a synergy of anti-cancer effects compared to an agent that inhibits one or the other kinases.

The research article by Liu et al describes MLS-2384 which is a synthetic derivative of amarine natural product, 6-bromoindirubin-3Œ-oxime. MLS-2384 exhibits a dual JAK/Src kinase inhibitory activity, blocks downstream signaling into the STAT3 pathway, and has anti-cancer activity in various human cancer cell lines.

These findings have important clinical implications for understanding the mechanisms of action of bromoindirubin derivatives.

The findings also indicate that this new 6-bromoindirubin derivative, MLS-2384, has potential as an anti-tumor therapeutic agent targeting JAK and Src kinases upstream of STAT3 in a wide variety of human cancer cells.

For the full report by Liu et al. in Cancer Biology & Therapy, visit the following link: https://www.landesbioscience.com/journals/cbt/article/26721/relevant and high-impact original research with a special focus on the

Published by Landes Bioscience since 2002, Cancer Biology & Therapy publishes molecular basis of cancer, including articles with translational relevance to diagnosis or therapy. Established in 2002, Landes Bioscience is an Austin, Texas-based publisher of biology research journals and books.

Andrew Thompson | EurekAlert!
Further information:
http://www.landesbioscience.com

More articles from Life Sciences:

nachricht The malaria pathogen’s cellular skeleton under a super-microscope
18.04.2014 | Helmholtz-Zentrum für Infektionsforschung

nachricht Synapses – stability in transformation
17.04.2014 | Max Planck Institute of Neurobiology, Martinsried

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

Siemens at the 2014 UIC ERTMS World Conference in Istanbul

01.04.2014 | Event News

AERA Meeting: German and US-American educational researchers in dialogue

28.03.2014 | Event News

WHS Regional Meeting: International experts address health challenges in Latin America

24.03.2014 | Event News

 
Latest News

A cross-section of the Universe

18.04.2014 | Physics and Astronomy

More, bigger wildfires burning western U.S., study shows

18.04.2014 | Studies and Analyses

High disease load reduces mortality of children

18.04.2014 | Social Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>