Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Defect in transport system cause DNA chaos in red blood cells

13.03.2012
Within all our cells lies two meters of DNA, highly ordered in a structure of less than 10 micro meters in diameter. Special proteins called histones act as small building bricks, organising our DNA in this structure.
Preservation of the structure is necessary to maintain correct function of our genes, making histones detrimental for maintaining a healthy and functional body. The research group of Associate Professor Anja Groth from BRIC, University of Copenhagen, has just elucidated a function of the protein Codanin-1, shedding light on the rare anemic disease CDAI where development of the red blood cells is disturbed. The new results also contribute with important knowledge on how our DNA-structure is maintained and how our genes are regulated.

"We became interested in Codanin-1 as it was well-known that mutations in the gene cause CDAI, whereas the function of the protein was entirely unknown. Our new results show that Codanin-1 is detrimental for the transport of newly synthesized histones and for the ordering of our DNA, when our cells are dividing. As this function is partly defect in CDAI, we could use the disease as a model to gain important knowledge in some of the basic processes that are crucial for normal cell division and development," says Associate Professor and group leader, Anja Groth.

Loss of guard function result in defective blood cells
Our DNA is copied and each identical copy is passed on to each of the two daughter cells when our cells divide. The ordered DNA structure also needs to be copied, which demands a constant supply of new histones. The histones are transported into the nucleus of our cells, through a molecular transportation system. Here they serve as small bricks that the DNA is wrapped around in an orderly structure, guided by information carried by the histones. The new results show that codanin-1 is crucial for the regulation of the histone transport. Mutations in Codanin-1 make the protein incapable of regulating the transport, giving rise to defects in the development of the red blood cells.

"Codanin-1 appears to function as a guard, which we think can detect internal and external signals to our cells. The protein then regulates the transport of new histones to the nucleus of our cells, based on this information. This transportation mechanism is defect in patients with CDAI, and for some reason that we do not yet fully understand, does this primarily affect the red blood cells," says postdoc Zuzana Jasencakova, who has been responsible for the laboratory experiments together with Ph.D. student Katrine Ask.

Basal biology and disease research goes hand in hand
Anja Groth’s research group intensively studies the basal biological mechanisms that control our DNA-structure and thereby the activity of our genes. Accordingly, they normally work with general biological model systems, but for this project, they used the characteristic of the disease CDAI to answer some basal biological questions:

"It is mostly the other way around, that basal biological findings are used to understand the development of disease. But here, we have used the defect protein of CDAI to elucidate some basal biological mechanisms. The fact that Codanin-1 serves a detrimental role in all our cells, but that defects primarily affect the red blood cells is very interesting. Hopefully we can use this detail to gain further knowledge on how our cells maintain a correct DNA-structure and regulates the genes," says Anja Groth.

The results have just been published in EMBO Journal: ”Codanin-1, mutated in the anaemic diesease CDAI, regulates Asf1 function in S-phase histone supply” , Ask et al, EMBO March 2012.

Contact:

Associate Professor Anja Groth, BRIC
Phone: +45 35325538
Mobile: +45 30507307

Postdoc Zuzana Jasencakova, BRIC
Phone: +45 35325833

Anja Groth | EurekAlert!
Further information:
http://www.ku.dk

More articles from Life Sciences:

nachricht Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

17.01.2017 | Materials Sciences

Smart homes will “LISTEN” to your voice

17.01.2017 | Architecture and Construction

VideoLinks
B2B-VideoLinks
More VideoLinks >>>