Prof. Eugene “Gene” Myers, one of the pioneers in bioinformatics, is affiliated with the group as a mentor. Together with his laboratory at the Max Planck Center for Systems Biology in Dresden, the junior group will decipher and compare the genetic codes of several flatworm species.
Flatworms are masters of regeneration, and are, therefore, interesting for scientists: If they are cut in two pieces, each half will develop into a new worm. By comparing the genetic material, researchers hope to gain new insights into regeneration of tissue that could have a huge impact on medicine.A new junior research group for Computational Biology (CBI) has been established at Heidelberg Institute for Theoretical Studies (HITS). It complements the work of the other six research groups, which carry out basic research in different fields of science. The focus lies on the processing and structuring of large data volumes. The leader of the new group is Dr. Siegfried Schloissnig, a 33-year-old Computer Scientist with a Doctorate in Human Biology, who previously worked as a PostDoc at the European Molecular Biology Laboratory (EMBL). A PostDoc and two PhD students will work under his leadership in Heidelberg.
New approaches to the de novo assemblyThe new junior research group at HITS will also work on these objectives in collaboration with Gene Myers’ laboratory in Dresden and the recently established Dresden Genome Center. Together with his group, Siegfried Schloissnig will develop new approaches to the so-called de novo assembly, which is the reconstruction of genome sequences by means of DNA sequencers and bioinformatic methods. In the course of sequencing by standard methods, DNA is copied multiple times. These copies are randomly split up into numerous small fragments. These fragments are examined for overlaps by means of bioinformatic methods and are subsequently reassembled. The smaller the fragments and the more complex the genome of interest, the more complicated is the problem. The situation becomes even more difficult, when no comparable genome is available and researchers have to assemble the genome de novo, i.e. anew. This is exactly the case with flatworms, whose genetic codes the HITS junior group plans to decipher.
Dr. Peter Saueressig | idw
Research team of the HAW Hamburg reanimated ancestral microbe from the depth of the earth
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Researchers Imitate Molecular Crowding in Cells
01.03.2017 | Universität Basel
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
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09.02.2017 | Event News
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01.03.2017 | Life Sciences