Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Crucial role for molecule in muscle development

05.07.2011
Research led by the University of East Anglia has discovered the crucial role of a molecule in skeletal muscle development.

The finding could have implications in the future for maintenance of healthy muscle or muscle regeneration in certain diseases, for example cancer and neuromuscular conditions such as muscular dystrophy.

The complexity and significance of microRNA molecules has only recently been recognized and they have been implicated in many biological processes, including disease. Until now nothing was known about their role in the development of skeletal muscle, which is pivotal for movement and supports healthy ageing.

Published this week in the journal Proceedings of the National Academy of Sciences (PNAS), the study was carried out by researchers in the School of Biological Sciences at UEA and the Weizmann Institute of Science, in Rehovot, Israel.

They showed that a particular microRNA, called miR-206, is crucial for normal muscle development in the embryo. MiR-206 switches off a gene called Pax3, this in turn allows early stage muscle cells to become more specialised contractile cells needed for muscle to function. The researchers suggest that this regulation is also important in adult muscle stem cells, which differentiate in response to muscle injury or exercise.

Lead author Andrea Münsterberg, professor in developmental biology at UEA, said: "Muscle is vital to our well being, but it can become fragile, for example as we age or through muscle-wasting diseases. Therefore understanding how muscle tissue develops and is maintained is important."

"Discovering how the Pax3 gene is regulated by miR-206 and controls other genes that lead to muscle differentiation is significant. If you control Pax3 you could control when cells become more specialised and take on their unique function. We suggest that what we have learnt about embryo development also applies to adult muscle."

Prof Münsterberg added: "While not the focus of this study, in theory if we could enhance the function of microRNAs in the body we might in the future be able to promote the maintenance of healthy muscle or muscle regeneration in certain diseases."

The study, 'MicroRNA regulation of the paired-box transcription factor Pax3 confers robustness to developmental timing of myogenesis', is published in Proceedings of the National Academy of Sciences (PNAS): www.pnas.org/content/early/recent

Cat Bartman | EurekAlert!
Further information:
http://www.uea.ac.uk
http://www.pnas.org/content/early/recent

More articles from Life Sciences:

nachricht A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>