Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Crucial role for molecule in muscle development

05.07.2011
Research led by the University of East Anglia has discovered the crucial role of a molecule in skeletal muscle development.

The finding could have implications in the future for maintenance of healthy muscle or muscle regeneration in certain diseases, for example cancer and neuromuscular conditions such as muscular dystrophy.

The complexity and significance of microRNA molecules has only recently been recognized and they have been implicated in many biological processes, including disease. Until now nothing was known about their role in the development of skeletal muscle, which is pivotal for movement and supports healthy ageing.

Published this week in the journal Proceedings of the National Academy of Sciences (PNAS), the study was carried out by researchers in the School of Biological Sciences at UEA and the Weizmann Institute of Science, in Rehovot, Israel.

They showed that a particular microRNA, called miR-206, is crucial for normal muscle development in the embryo. MiR-206 switches off a gene called Pax3, this in turn allows early stage muscle cells to become more specialised contractile cells needed for muscle to function. The researchers suggest that this regulation is also important in adult muscle stem cells, which differentiate in response to muscle injury or exercise.

Lead author Andrea Münsterberg, professor in developmental biology at UEA, said: "Muscle is vital to our well being, but it can become fragile, for example as we age or through muscle-wasting diseases. Therefore understanding how muscle tissue develops and is maintained is important."

"Discovering how the Pax3 gene is regulated by miR-206 and controls other genes that lead to muscle differentiation is significant. If you control Pax3 you could control when cells become more specialised and take on their unique function. We suggest that what we have learnt about embryo development also applies to adult muscle."

Prof Münsterberg added: "While not the focus of this study, in theory if we could enhance the function of microRNAs in the body we might in the future be able to promote the maintenance of healthy muscle or muscle regeneration in certain diseases."

The study, 'MicroRNA regulation of the paired-box transcription factor Pax3 confers robustness to developmental timing of myogenesis', is published in Proceedings of the National Academy of Sciences (PNAS): www.pnas.org/content/early/recent

Cat Bartman | EurekAlert!
Further information:
http://www.uea.ac.uk
http://www.pnas.org/content/early/recent

More articles from Life Sciences:

nachricht Designer cells: artificial enzyme can activate a gene switch
22.05.2018 | Universität Basel

nachricht Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Designer cells: artificial enzyme can activate a gene switch

22.05.2018 | Life Sciences

PR of MCC: Carbon removal from atmosphere unavoidable for 1.5 degree target

22.05.2018 | Earth Sciences

Achema 2018: New camera system monitors distillation and helps save energy

22.05.2018 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>