Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Complex pathogens: Effects of gastric bacterium Helicobacter pylori on other organs revealed

05.02.2016

Helicobacter pylori, a bacterium colonising the stomach, has a bad reputation: It is said to cause gastritis, stomach ulcers and, in the long run, even cancer. And yet, it seems the bacterium could also have some positive effects. A team of scientists from Graz and New York examined the impact of a Helicobacter infection on the stomach, intestines and lungs over a period of six months. The unexpected findings were published in the current edition of the prestigious journal Cell Reports.

Some two kilogrammes of bacteria live on and in our body. It is not always easy to distinguish between “good” and “bad” bacteria because their complex interactions have barely been explored. This is also true for Helicobacter pylori. “We do know, for example, that in societies where the prevalence of Helicobacter is high, children suffer less frequently from asthma”, says Dr. Sabine Kienesberger of the Institute of Molecular Biosciences at the University of Graz, lead author of the paper in Cell Reports.


Sabine Kienesberger-Feist

Photo: Uni Graz/Lunghammer


The scientists discovered various interesting relationships: “Our investigations have shown that a Helicobacter infection leads to an accumulation of specific T-cells in the lungs. These cells play an important role in our immune system”, Kienesberger says.

The team was particularly surprised to see that a Heliobacter infection also entails changes in the composition of the intestinal flora which can, in turn, stimulate the immune system. The researchers also found shifts in hormonal balance. “The concentration of the ‘hunger hormone’ ghrelin, for example, increased. Excessive production of this hormone stimulates the appetite. Ghrelin is also known to have an impact on the immune system”, Kienesberger adds.

What makes this study so special is the long-term observation of the Helicobacter infection and its effects in the mouse model as a dynamic process over an extended period. Kienesberger: “The early and to some extent contradictory effects on the lungs came as a surprise, even though an increased immune reaction in the stomach was noted only later.” The study provides a sound basis for further research and targeted investigation of the complex interactions of Helicobacter, microbiome and the immune system.

Kienesberger cooperated with colleagues from the University of Graz, the Medical University of Graz, and from New York University School of Medicine for this publication. She carried out the major part of her investigations during her 30-month postdoc programme in New York where she worked in the team of Prof. Dr. Martin Blaser, a pioneer in microbiome research. At the University of Graz she is a member of Univ.-Prof. Dr. Ellen Zechner’s working group. The study was undertaken in the framework of BioTechMed-Graz, the joint research initiative of the University of Graz, the Medical University of Graz and Graz University of Technology.

Publication:
Gastric Helicobacter pylori Infection Affects Local and Distant Microbial Populations and Host Responses
Sabine Kienesberger, Laura M. Cox, Alexandra Livanos, Xue-Song Zhang, Jennifer Chung, Guillermo I. Perez-Perez, Gregor Gorkiewicz, Ellen L. Zechner, and Martin J. Blaser
Cell Reports, February 16, 2016

Contact:
Dr. Sabine Kienesberger-Feist
Institute of Molecular Biosciences at the University of Graz, Austria
Phone: +43 (0)316/380-5505
E-mail: sabine.kienesberger@uni-graz.at

Mag. Gudrun Pichler | Karl-Franzens-Universität Graz
Further information:
http://www.uni-graz.at

More articles from Life Sciences:

nachricht Warming ponds could accelerate climate change
21.02.2017 | University of Exeter

nachricht An alternative to opioids? Compound from marine snail is potent pain reliever
21.02.2017 | University of Utah

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Impacts of mass coral die-off on Indian Ocean reefs revealed

21.02.2017 | Earth Sciences

Novel breast tomosynthesis technique reduces screening recall rate

21.02.2017 | Medical Engineering

Use your Voice – and Smart Homes will “LISTEN”

21.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>