Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Colorful Columns

25.05.2009
Simple method for the production of microcylinders with multiple compartments

Under a microscope they look like tiny pie charts or colorful candy canes: A team led by Joerg Lahann at the University of Michigan (USA) has been able to produce micrometer-wide discs and elongated rods precisely built out of multicolored compartments.

As reported in the journal Angewandte Chemie, these scientists have developed a simple, cost-effective, reliable, and scalable method for the production of microcylinders with multiple compartments. The inner structure, aspect ratio, and surface chemistry can be tuned by means of the new production method which is based on electrodynamic co-spinning and microcutting processes.

Bicolor cylinders were made by pumping two differently colored biodegradable polymer solutions through two side-by-side jets. An electrical field stretches the exiting drops, resulting in a bicompartmental fiber that is “spun” into a bundle of parallel individual fibers. The researchers embed the 1 cm long fiber bundles in a gel, which they then freeze. Using a microtome, they slice off thin sections. Upon dissolution of the gel in water and treatment with ultrasound, the bundles can be separated into individual cylinders of uniform size. The length of the cylinders depends on the thickness of the microtome sections, which allows for the production of everything from flat discs to long rods.

If more than two jets are used, it is possible to make fibers out of three, four, or more different components. Depending on the arrangement of the jets, different patterns can be generated. For example, it is possible to fabricate cylindrical particles that look like a three-section or four-section pie chart. If the jets are positioned next to each other, the result is a striped structure. The individual segments are always identical in size and are clearly delineated.

Instead of dyeing the components, it is also possible to attach various (bio-)reagents to the segments of the cylinders if specific “anchor sites” are built into the polymer. Special shapes can also be produced when one or more segments are made of a polymer that can be selectively dissolved. For example, one fourth of a four-component cylinder can be removed to make a rod with a groove.

The new method can be used to produce particles made of precisely designed compartments with mutually independent physical and chemical properties. Possible areas of application include drug transport, tissue culture, and bundled biotests, as well as “intelligent displays” and reactive materials.

Author: Joerg Lahann, University of Michigan, Ann Arbor (USA), http://www.engin.umich.edu/dept/cheme/people/lahann.html

Title: Multicompartmental Microcylinders

Angewandte Chemie International Edition, doi: 10.1002/anie.200806241

Joerg Lahann | Angewandte Chemie
Further information:
http://pressroom.angewandte.org
http://www.engin.umich.edu/dept/cheme/people/lahann.html

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>