Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Colorful Columns

25.05.2009
Simple method for the production of microcylinders with multiple compartments

Under a microscope they look like tiny pie charts or colorful candy canes: A team led by Joerg Lahann at the University of Michigan (USA) has been able to produce micrometer-wide discs and elongated rods precisely built out of multicolored compartments.

As reported in the journal Angewandte Chemie, these scientists have developed a simple, cost-effective, reliable, and scalable method for the production of microcylinders with multiple compartments. The inner structure, aspect ratio, and surface chemistry can be tuned by means of the new production method which is based on electrodynamic co-spinning and microcutting processes.

Bicolor cylinders were made by pumping two differently colored biodegradable polymer solutions through two side-by-side jets. An electrical field stretches the exiting drops, resulting in a bicompartmental fiber that is “spun” into a bundle of parallel individual fibers. The researchers embed the 1 cm long fiber bundles in a gel, which they then freeze. Using a microtome, they slice off thin sections. Upon dissolution of the gel in water and treatment with ultrasound, the bundles can be separated into individual cylinders of uniform size. The length of the cylinders depends on the thickness of the microtome sections, which allows for the production of everything from flat discs to long rods.

If more than two jets are used, it is possible to make fibers out of three, four, or more different components. Depending on the arrangement of the jets, different patterns can be generated. For example, it is possible to fabricate cylindrical particles that look like a three-section or four-section pie chart. If the jets are positioned next to each other, the result is a striped structure. The individual segments are always identical in size and are clearly delineated.

Instead of dyeing the components, it is also possible to attach various (bio-)reagents to the segments of the cylinders if specific “anchor sites” are built into the polymer. Special shapes can also be produced when one or more segments are made of a polymer that can be selectively dissolved. For example, one fourth of a four-component cylinder can be removed to make a rod with a groove.

The new method can be used to produce particles made of precisely designed compartments with mutually independent physical and chemical properties. Possible areas of application include drug transport, tissue culture, and bundled biotests, as well as “intelligent displays” and reactive materials.

Author: Joerg Lahann, University of Michigan, Ann Arbor (USA), http://www.engin.umich.edu/dept/cheme/people/lahann.html

Title: Multicompartmental Microcylinders

Angewandte Chemie International Edition, doi: 10.1002/anie.200806241

Joerg Lahann | Angewandte Chemie
Further information:
http://pressroom.angewandte.org
http://www.engin.umich.edu/dept/cheme/people/lahann.html

More articles from Life Sciences:

nachricht Discovery of a Key Regulatory Gene in Cardiac Valve Formation
24.05.2017 | Universität Basel

nachricht Carcinogenic soot particles from GDI engines
24.05.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>