Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Collagen for the knee

25.04.2014

Cartilage damage is the most common form of joint disease. Recently, the German biotechnology company Amedrix has developed collagen implants for damaged cartilage that allow cells from surrounding tissues to migrate into the implants. The processes for collagen purification as well as GMP-compliant manufacturing of the collagen implants were developed in cooperation with the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB.

Five million people suffer cartilage damage to the knee every year in Germany. Cartilage injuries are not only painful; they can lead to osteoarthritis decades later. In the course of the disease, the protective shock absorbing cartilage that covers the bone within the joint slowly is removed until the bone is finally exposed, typically requiring an artificial joint replacement.


Collagen for company Amedrix is processed in the GMP-unit at the Fraunhofer IGB.

© Fraunhofer IGB


The liquid collagen implant is arthroscopically injected with a special syringe.

© Fraunhofer IGB

An early alternative to the artificial knee joint are biological therapies, such as autologous chondrocyte implantation (ACI), where chondrocytes are isolated from a small piece of cartilage of the patient, expanded in the laboratory and after three weeks implanted into the defect, often in combination with a shaping matrix.

Over time, the implanted cells will reconstruct the matrix until the injured cartilage is completely regenerated. However, the cost of treatment is high and not always fully reimbursed by health insurance. In addition, two surgical interventions are always required: one to remove the cartilage cells and a second to implant the proliferated cells.

The German biotechnology company Amedrix GmbH developed a one-step minimally-invasive surgical procedure for the treatment of cartilage defects using their cell-free collagen implants – with comparable good autoregeneration of the cartilage defects. Their first gel-like implant was approved for the European market in 2012. In December 2013 a further development of this product, a liquid application form, received European CE certification, which ensures that the implant is safe and medically-technically efficient.

"Our new product is arthroscopically injected as a liquid collagen implant. Once injected, the liquid collagen forms a stable cartilage replacement in minutes", describes Dr. Thomas Graeve, CEO of Amedrix. After injection, cartilage and stem cells from the surrounding tissue migrate into the implant and stimulate the self-healing of the cartilage. Within a short time, the result is a new and resilient cartilage. “Patient MRI studies show that the cartilage defect is nearly completely filled after six months", says Graeve.

In order to optimize the purification and manufacturing process according to current legal regulations, Amedrix cooperates with the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB in Stuttgart. The institute supports a 215-square-meter Good Manufacturing Practice (GMP) unit certified for developing production processes for medical devices or cell-based tissue-engineered products.

"Our specially trained staff work together with Amedrix employees to isolate collagen protein from animal tendons and then process the collagen in the IGB clean rooms," explains Markus Schandar, head of the GMP Group.

The Fraunhofer IGB has also applied for the manufacturing authorization of medicinal products on behalf of industrial partners. "Previously, we have developed GMP processes for autologous endothelial cells for the colonization of a vascular prostheses, autologous cartilage grafts and autologous bone marrow stem cells for regenerative medicine under GMP conditions and according to the guidelines of the Medicines Act", according to Schandar.

Markus Schandar | Fraunhofer-Institute
Further information:
http://www.igb.fraunhofer.de/en/press-media/press-releases/2014/collagen-knee.html

Further reports about: Biotechnology Collagen GMP IGB Interfacial MRI cartilage damage protein

More articles from Life Sciences:

nachricht Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

17.01.2017 | Materials Sciences

Smart homes will “LISTEN” to your voice

17.01.2017 | Architecture and Construction

VideoLinks
B2B-VideoLinks
More VideoLinks >>>