"Although MDMA and cocaine are psychoactive substances frequently used by teenagers, very few studies have been done to analyse the short and long-term consequences of joint exposure to these drugs", José Miñarro, lead author of the study and coordinator of the Psychobiology of Drug Addiction group at the UV, tells SINC.
The study, published in the journal Addiction Biology, shows for the first time that exposure to these drugs during adolescence leads to long-lasting changes that increase the reinforcing power of ecstasy or MDMA, and which last until adulthood.
Miñarro's team studied the joint consumption of different drugs in order to carry out an in-depth examination into the effects of this interaction. The scientists administered MDMA, cocaine and saline solution to mice over an eight-day period. "The animals exhibited an increase in vulnerability to re-establishing behaviour (relapse), showing a preference for certain environments previously associated with the pleasant effects of the drug", explains Miñarro.
The results highlight that the so-called "reinforcing effects" are greater in adult mice treated with ecstasy or cocaine during adolescence than in adolescent mice not exposed to these drugs. "Adolescence is a critical stage in development, during which time drug consumption affects plastic cerebral processes in ways that cause changes that persist right through to adulthood", adds the scientist.
Adolescence – the kingdom of polyconsumption
The results of various surveys, both national and international, show that one of the most common patterns of drug use is polyconsumption. Ecstasy is regularly consumed alongside other drugs such as alcohol, cannabis and cocaine. These same surveys show that 44% of cocaine users in Spain also take ecstasy, and this consumption takes place primarily during adolescence.
The State Study on Drug Use among Secondary School Students (ESTUDES 2007, Government Delegation for the National Plan on Drugs), showed that more than 75% of secondary school students who reported taking MDMA also said they used cocaine, while only 44.3% of cocaine users said they took ecstasy.
References: Manuel Daza-Losada, Marta Rodríguez-Arias, María A. Aguilar & José Miñarro. "Acquisition and reinstatement of MDMA-induced conditioned place preference in mice pre-treated with MDMA or cocaine during adolescence". Addiction Biology 14, 447-456, octubre de 2009.
SINC | EurekAlert!
Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH
Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences