Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Chemists Devise Better Way to Prepare Workhorse Molecules

14.06.2011
In chemistry, so-called aromatic molecules compose a large and versatile family of chemical compounds that are the stuff of pharmaceuticals, electronic materials and consumer products ranging from sunscreen to plastic soda bottles.

Writing in the current online issue (June 9) of the journal Science, a team led by University of Wisconsin-Madison chemistry Professor Shannon Stahl reports a new, environmentally friendly way to make substituted aromatic molecules that can be customized for different industrial needs.

As college chemistry students know, aromatic molecules have a special stability conferred by a ring of six carbon atoms with alternating single and double bonds. “The ultimate utility of these molecules depends on the chemical groups attached at the corners of this hexagonal platform,” explains Stahl. “Interest in preparing substituted aromatic molecules traces back to the dawn of organic chemistry.”

In fact, the 2010 Nobel Prize in Chemistry was awarded for catalytic chemical reactions that allow the introduction of specific groups to the periphery of aromatic molecules. These methods, and older traditional methods, rely on modifying an existing aromatic molecule, Stahl explains. But the stability of aromatic molecules can make such approaches difficult, and existing methods also have many limitations in the types and patterns of chemical groups that can be installed.

The method devised by Stahl and Wisconsin colleagues Yusuke Izawa and Doris Pun owes its success to the discovery of a new palladium catalyst. The catalyst gives chemists a way to peel off hydrogen from cyclic molecules to form aromatic products with the desired substitution patterns already in place. The hydrogen removed by the palladium catalyst is combined with oxygen, and water is formed as the only byproduct.

The Wisconsin team demonstrated the utility and efficiency of the new process on phenols, aromatic compounds that are produced on a large scale as precursors to many kinds of industrial materials and pharmaceutical agents. While the new catalytic method can be used to make a broad spectrum of aromatic molecules of interest to science and industry, the new work will be of most immediate practical use to drug companies, according to Stahl. For example, an anticancer agent that was difficult to make using previously known methods was efficiently produced using the strategy devised by the team.

Stahl notes that the work published today in Science will require more development before it is suitable for large-scale industrial production, but he emphasizes that concepts introduced by the new work will have broad utility. “Many new catalysts, reaction conditions and target molecules can be envisioned. Overall, this route to substituted aromatic molecules has a lot of potential,” he says.

The new study was supported by grants from the U.S. National Institutes of Health, the Mitsubishi Chemical Corp. and the U.S. National Science Foundation.

Terry Devitt | Newswise Science News
Further information:
http://www.wisc.edu

Further reports about: Devise Molecules Workhorse carbon atom chemical reaction palladium catalyst

More articles from Life Sciences:

nachricht Meadows beat out shrubs when it comes to storing carbon
23.11.2017 | Norwegian University of Science and Technology

nachricht Migrating Cells: Folds in the cell membrane supply material for necessary blebs
23.11.2017 | Westfälische Wilhelms-Universität Münster

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Frictional Heat Powers Hydrothermal Activity on Enceladus

Computer simulation shows how the icy moon heats water in a porous rock core

Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Underwater acoustic localization of marine mammals and vehicles

23.11.2017 | Information Technology

Enhancing the quantum sensing capabilities of diamond

23.11.2017 | Physics and Astronomy

Meadows beat out shrubs when it comes to storing carbon

23.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>