Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Chemical Chaperones Have Helped Proteins Do Their Jobs for Billions of Years

21.02.2014
An ancient chemical, present for billions of years, appears to have helped proteins function properly since time immemorial.

Proteins are the body's workhorses, and like horses they often work in teams. There exists a modern day team of multiple chaperone proteins that help other proteins fold into the complex 3D shapes they must achieve to function. This is necessary to avert many serious diseases caused when proteins misbehave.

But what happened before this team of chaperones was formed? How did the primordial cells that were the ancestors of modern life keep their proteins folded and functional?

Scientists from the University of Michigan discovered that an extremely simple, ancient chemical called polyphosphate can perform the role of a chaperone. It likely played that role billions of years ago, and still keeps its old job today.

"Polyphosphate has likely been present since life began on Earth, and is thought to exist in all living creatures," said postdoctoral researcher Michael Gray. "This means it's extremely important, but no one really knew what it was for.

"We found that bacteria accumulate polyphosphate to defend against disease-causing, protein unfolding conditions. Purified polyphosphate works well to protect proteins in the test tube, showing that this simple chemical can substitute for the complex team of protein chaperones."

The discovery unravels a long­standing evolutionary mystery that could lead to new strategies for treating protein folding diseases such as Alzheimer's and Parkinson's, which occur when proteins misfold or pile up.

"Once we know how to manipulate the levels of polyphosphate in cells and organisms, we should be able to improve protein folding and develop countermeasures against protein folding diseases," said Ursula Jakob, the U-M professor in charge of the research.

Their work appears in the journal Molecular Cell. It was funded by the National Institutes of Health and Howard Hughes Medical Institute. U-M co-­authors include Wei-­Yun Wholey, Claudia Cremers, Robert Bender, Antje Mueller-Schickert, Nico Wagner, Nathaniel Hock, Adam Krieger, Erica Smith and James Bardwell.

Laura Bailey | Newswise
Further information:
http://www.umich.edu

More articles from Life Sciences:

nachricht Protein Shake-Up
27.03.2015 | Oak Ridge National Laboratory

nachricht How did the chicken cross the sea?
27.03.2015 | Michigan State University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Experiment Provides the Best Look Yet at 'Warm Dense Matter' at Cores of Giant Planets

In an experiment at the Department of Energy's SLAC National Accelerator Laboratory, scientists precisely measured the temperature and structure of aluminum as...

Im Focus: Energy-autonomous and wireless monitoring protects marine gearboxes

The IPH presents a solution at HANNOVER MESSE 2015 to make ship traffic more reliable while decreasing the maintenance costs at the same time. In cooperation with project partners, the research institute from Hannover, Germany, has developed a sensor system which continuously monitors the condition of the marine gearbox, thus preventing breakdowns. Special feature: the monitoring system works wirelessly and energy-autonomously. The required electrical power is generated where it is needed – directly at the sensor.

As well as cars need to be certified regularly (in Germany by the TÜV – Technical Inspection Association), ships need to be inspected – if the powertrain stops...

Im Focus: 3-D satellite, GPS earthquake maps isolate impacts in real time

Method produced by UI researcher could improve reaction time to deadly, expensive quakes

When an earthquake hits, the faster first responders can get to an impacted area, the more likely infrastructure--and lives--can be saved.

Im Focus: Atlantic Ocean overturning found to slow down already today

The Atlantic overturning is one of Earth’s most important heat transport systems, pumping warm water northwards and cold water southwards. Also known as the Gulf Stream system, it is responsible for the mild climate in northwestern Europe. 

Scientists now found evidence for a slowdown of the overturning – multiple lines of observation suggest that in recent decades, the current system has been...

Im Focus: Robot inspects concrete garage floors and bridge roadways for damage

Because they are regularly subjected to heavy vehicle traffic, emissions, moisture and salt, above- and underground parking garages, as well as bridges, frequently experience large areas of corrosion. Most inspection systems to date have only been capable of inspecting smaller surface areas.

From April 13 to April 17 at the Hannover Messe (hall 2, exhibit booth C16), engineers from the Fraunhofer Institute for Nondestructive Testing IZFP will be...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

World Conference On Regenerative Medicine 2015: Registration And Abstract Submission Now Open

25.03.2015 | Event News

University presidents from all over the world meet in Hamburg

19.03.2015 | Event News

10. CeBiTec Symposium zum Big Data-Problem

17.03.2015 | Event News

 
Latest News

Two Most Destructive Termite Species Forming Superswarms in South Florida

27.03.2015 | Agricultural and Forestry Science

ORNL-Led Team Demonstrates Desalination with Nanoporous Graphene Membrane

27.03.2015 | Materials Sciences

Coorong Fish Hedge Their Bets for Survival

27.03.2015 | Ecology, The Environment and Conservation

VideoLinks
B2B-VideoLinks
More VideoLinks >>>