The study, directed by the center’s director Giulio Superti-Furga, appears today in the online advanced publication route of the journal Nature Immunology. The newly discovered protein, termed AIM2, patrols the inside of human immune cells and when it encounters a DNA that is suspicious, possibly coming from an intruding virus or bacterium, triggers the secretion of the signaling protein Interleukin-1.
This proinflammatory molecule activates an anti-invasion alarm program throughout the entire body. It is one of the main causes of fever and a central mediator of autoimmune disease. Thus, the study identified a new centerpiece of the human’s defense arsenal against pathogens.
“We are excited about this molecule as it helps understand the body’s immediate reaction to infections. It is much too early to say, but in the future AIM2 could lead to ways to enhance the patients’ own protection when this is needed, as during epidemics or when otherwise immune depressed”, stresses Tilmann Bürckstümmer, the first author of the study.
The results derived from a large scale, systematic search for human proteins that bind pathogenic molecules. Three other groups from Worcester, Philadelphia and Adelaide report the identification of the same protein in parallel publications appearing in the journals Nature and Science. This fact stresses the importance of the discovery made at CeMM.
“I am very proud that our new research center could contribute to such a fundamental immunology finding. It shows that CeMM as an Austrian research organization competes in the top-league of international research only a few years after being founded and before entering its new building. We are eager to collaborate with our clinical partners at the Medical University of Vienna to investigate if malfunction of the protein may be associated with autoimmune disease, when too much inflammatory signals are produced”, adds Giulio Superti-Furga.
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Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
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26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy