Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

CeMM Discovers Antiviral Protein

22.01.2009
The Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM) announces the discovery of a new molecular sensor in human cells capable of recognizing infecting viruses and transmitting an alarm signal to the body.

The study, directed by the center’s director Giulio Superti-Furga, appears today in the online advanced publication route of the journal Nature Immunology. The newly discovered protein, termed AIM2, patrols the inside of human immune cells and when it encounters a DNA that is suspicious, possibly coming from an intruding virus or bacterium, triggers the secretion of the signaling protein Interleukin-1.

This proinflammatory molecule activates an anti-invasion alarm program throughout the entire body. It is one of the main causes of fever and a central mediator of autoimmune disease. Thus, the study identified a new centerpiece of the human’s defense arsenal against pathogens.

“We are excited about this molecule as it helps understand the body’s immediate reaction to infections. It is much too early to say, but in the future AIM2 could lead to ways to enhance the patients’ own protection when this is needed, as during epidemics or when otherwise immune depressed”, stresses Tilmann Bürckstümmer, the first author of the study.

The results derived from a large scale, systematic search for human proteins that bind pathogenic molecules. Three other groups from Worcester, Philadelphia and Adelaide report the identification of the same protein in parallel publications appearing in the journals Nature and Science. This fact stresses the importance of the discovery made at CeMM.

“I am very proud that our new research center could contribute to such a fundamental immunology finding. It shows that CeMM as an Austrian research organization competes in the top-league of international research only a few years after being founded and before entering its new building. We are eager to collaborate with our clinical partners at the Medical University of Vienna to investigate if malfunction of the protein may be associated with autoimmune disease, when too much inflammatory signals are produced”, adds Giulio Superti-Furga.

Leopold Liechtenstein | alfa
Further information:
http://www.cemm.at
http://www.cemm.oeaw.ac.at

More articles from Life Sciences:

nachricht Immune Defense Without Collateral Damage
23.01.2017 | Universität Basel

nachricht The interactome of infected neural cells reveals new therapeutic targets for Zika
23.01.2017 | D'Or Institute for Research and Education

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

23.01.2017 | Health and Medicine

Electrocatalysis can advance green transition

23.01.2017 | Physics and Astronomy

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>