Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cell binding discovery brings hope to those with skin and heart problems

21.01.2011
A University of Manchester scientist has revealed the mechanism that binds skin cells tightly together, which he believes will lead to new treatments for painful and debilitating skin diseases and also lethal heart defects.

Professor David Garrod, in the Faculty of Life Sciences, has found that the glue molecules bind only to similar glue molecules on other cells, making a very tough, resilient structure. Further investigation on why the molecules bind so specifically could lead to the development of clinical applications.

Professor Garrod, whose Medical Research Council-funded work is paper of the week in the Journal of Biological Chemistry (JBC) tomorrow (Friday), said: "Our skin is made up of three different layers, the outermost of which is the epidermis. This layer is only about 1/10th of a millimetre thick yet it is tough enough to protect us from the outside environment and withstand the wear and tear of everyday life.

"One reason our epidermis can do this is because its cells are very strongly bound together by tiny structures called desmosomes, sometimes likened to rivets. We know that people who have defects in their desmosomes have problems with their epidermis and get extremely unpleasant skin diseases. Understanding how desmosomes function is essential for developing better treatments for these and other types of skin disease and for non-healing wounds.

"Desmosomes are also extremely important in locking together the muscle cells of the heart, and hearts where desmosomes are defective can fail catastrophically, causing sudden death in young people.

Hence our findings may also be relevant in the heart and in developing new treatments for heart disease."

ProfessorGarrod and his team, Zhuxiang Nie, Anita Merritt, Mansour Rouhi and Lydia Tabernero, used chemical cross-linking to study cells of the epidermis and found what they believe to be the principal mechanism by which the glue molecules of desmosomes of skin cells bind to each other.

"For reasons that we do not fully understand there are several different but closely-related glue molecules within each desmosome," he explained.

"Our results show that each glue molecule on one cell binds primarily to another of the same type on the neighbouring cell, meaning the binding is highly specific. This was very surprising because previous studies using different techniques had not been able to give such a clear answer on the specificity of binding."

He added: "Our result suggests that this type of specific binding is of fundamental importance in locking together cells of the epidermis into a tough, resilient structure. It is an important step forward in our research, which aims to develop better treatments for non-healing wounds, other skin diseases and heart problems. We could do this if we understood how to make medicines that would lock or unlock the desmosomes as required."

Aeron Haworth | EurekAlert!
Further information:
http://www.manchester.ac.uk

More articles from Life Sciences:

nachricht Bolstering fat cells offers potential new leukemia treatment
17.10.2017 | McMaster University

nachricht Ocean atmosphere rife with microbes
17.10.2017 | King Abdullah University of Science & Technology (KAUST)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Ocean atmosphere rife with microbes

17.10.2017 | Life Sciences

Neutrons observe vitamin B6-dependent enzyme activity useful for drug development

17.10.2017 | Life Sciences

NASA finds newly formed tropical storm lan over open waters

17.10.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>