Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cell binding discovery brings hope to those with skin and heart problems

21.01.2011
A University of Manchester scientist has revealed the mechanism that binds skin cells tightly together, which he believes will lead to new treatments for painful and debilitating skin diseases and also lethal heart defects.

Professor David Garrod, in the Faculty of Life Sciences, has found that the glue molecules bind only to similar glue molecules on other cells, making a very tough, resilient structure. Further investigation on why the molecules bind so specifically could lead to the development of clinical applications.

Professor Garrod, whose Medical Research Council-funded work is paper of the week in the Journal of Biological Chemistry (JBC) tomorrow (Friday), said: "Our skin is made up of three different layers, the outermost of which is the epidermis. This layer is only about 1/10th of a millimetre thick yet it is tough enough to protect us from the outside environment and withstand the wear and tear of everyday life.

"One reason our epidermis can do this is because its cells are very strongly bound together by tiny structures called desmosomes, sometimes likened to rivets. We know that people who have defects in their desmosomes have problems with their epidermis and get extremely unpleasant skin diseases. Understanding how desmosomes function is essential for developing better treatments for these and other types of skin disease and for non-healing wounds.

"Desmosomes are also extremely important in locking together the muscle cells of the heart, and hearts where desmosomes are defective can fail catastrophically, causing sudden death in young people.

Hence our findings may also be relevant in the heart and in developing new treatments for heart disease."

ProfessorGarrod and his team, Zhuxiang Nie, Anita Merritt, Mansour Rouhi and Lydia Tabernero, used chemical cross-linking to study cells of the epidermis and found what they believe to be the principal mechanism by which the glue molecules of desmosomes of skin cells bind to each other.

"For reasons that we do not fully understand there are several different but closely-related glue molecules within each desmosome," he explained.

"Our results show that each glue molecule on one cell binds primarily to another of the same type on the neighbouring cell, meaning the binding is highly specific. This was very surprising because previous studies using different techniques had not been able to give such a clear answer on the specificity of binding."

He added: "Our result suggests that this type of specific binding is of fundamental importance in locking together cells of the epidermis into a tough, resilient structure. It is an important step forward in our research, which aims to develop better treatments for non-healing wounds, other skin diseases and heart problems. We could do this if we understood how to make medicines that would lock or unlock the desmosomes as required."

Aeron Haworth | EurekAlert!
Further information:
http://www.manchester.ac.uk

More articles from Life Sciences:

nachricht Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Could a particle accelerator using laser-driven implosion become a reality?

24.05.2018 | Physics and Astronomy

Hot cars can hit deadly temperatures in as little as one hour

24.05.2018 | Health and Medicine

Complementing conventional antibiotics

24.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>