Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cause of Ageing Remains Elusive

22.10.2014

A report by Chinese researchers in the journal Nature a few months ago was a small sensation: they appeared to have found the cause for why organisms age. An international team of scientists, headed by the University of Bonn, has now refuted a basic assumption of the Nature article. The reasons for ageing thus remain elusive.

The Chinese article caused a stir amongst experts worldwide. Using a simple measurement in young nematode worms, the researchers reported they had been able to predict how long they would live .


The photo shows a nematode worm with its mitochondria fluorescing in yellow due to sensor staining; a structural model of the probe is shown in the foreground.

© Dr. Markus Schwarzländer, Uni Bonn

The researchers had introduced a fluorescent probe called cpYFP into the cellular power stations, the mitochondria, of the worms. Mitochondria are present in most living organisms. They provide the energy for all processes of life.

Many biologists consider the mitochondria an important biological clock that drives ageing. As an underlying cause they suspect that the highly reactive molecules, so called free radicals, released during energy conversion by the power stations can react with cellular molecules causing damage. As a result cellular performance decreases until the cell dies.

This theory is not new – it was first proposed nearly 40 years ago. However, until today it has not been possible to show a conclusive link between mitochondrial activity, the formation of free radicals and ageing. En-Zhi Shen and his colleagues appeared to have found a critical link. They used cpYFP as a free radical detector. And indeed: the more frequently the probe lit up in young worms - i.e. the more free radicals they appeared to produce -, the shorter the worms lived.

An international team of scientists has now refuted a basic assumption of this study. Their work shows that cpYFP is not able to measure free radicals in the first place. Instead the signals of the probe are the result of changes in pH (that is the acidity) inside the mitochondria.

"From the published worm data we cannot conclude that the degree of free radical release determines lifespan." says Dr. Markus Schwarzländer, research group leader at the University of Bonn and first author of the publication. "cpYFP is not suitable to address this question." He adds that the relationship between the occurance of the probe signals and lifespan of the worms was exciting nevertheless. “Now we can focus on trying to understand its actual significance.“
The new study is soon to appear, also in the journal Nature. 28 experts from 9 countries were involved in this work. It was led by scientists from the University of Bonn, from the German Cancer Research Center Heidelberg, as well as from the Medical Research Council in Cambridge, England.

Publication: Markus Schwarzländer et al.: The ‘mitoflash’ probe cpYFP does not respond to superoxide; Nature Volume 514 Edition 7523; doi: 10.1038/nature13858

Contact details:
Dr. Markus Schwarzländer
Head of the Emmy-Noether Research Group „Plant Energy Biology“
Institute of Crop Science and Ressource Conservation, University of Bonn
Phone: +40-(0)228-73-54266
E-Mail: markus.schwarzlander@uni-bonn.de

Dr. Andreas Archut | idw - Informationsdienst Wissenschaft
Further information:
http://www.uni-bonn.de/

More articles from Life Sciences:

nachricht 'Y' a protein unicorn might matter in glaucoma
23.10.2017 | Georgia Institute of Technology

nachricht Microfluidics probe 'cholesterol' of the oil industry
23.10.2017 | Rice University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Salmonella as a tumour medication

HZI researchers developed a bacterial strain that can be used in cancer therapy

Salmonellae are dangerous pathogens that enter the body via contaminated food and can cause severe infections. But these bacteria are also known to target...

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Symposium on Driving Simulation

23.10.2017 | Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

 
Latest News

Microfluidics probe 'cholesterol' of the oil industry

23.10.2017 | Life Sciences

Gamma rays will reach beyond the limits of light

23.10.2017 | Physics and Astronomy

The end of pneumonia? New vaccine offers hope

23.10.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>