The link is the enzyme Tankyrase and its pivotal role in switching on or off the protein that controls two known cancer genes. In normal cells, the protein is vital for bone development. In abnormal cells, it is thought to be involved in two common types of blood cancer – chronic myelogenous leukemia and acute myeloid leukemia.
The findings, published online today in CELL (DOI: 10.1016/j.cell.2011.10.046), zero in on how the enzyme alters the protein 3BP2, says principal investigator Dr. Robert Rottapel, clinician-scientist at The Campbell Family Institute for Cancer Research in the Princess Margaret Cancer Program, University Health Network and St. Michael’s Hospital. He is also a Professor, Faculty of Medicine, University of Toronto, and holds the Amgen Chair for Cancer Research.
“We have defined the rules of engagement for Tankyrase, which clearly identifies a potential target for developing therapeutic agents for human disease,” says Dr. Rottapel. These studies point the way for new therapeutic approaches in treating cherubism, using inhibitors that are already available in the clinic.
In a separate but related study (also published today) co-led by Dr. Rottapel and Dr. Frank Sicheri at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, the investigators further defined the structural details that define the interaction between Tankyrase and 3BP2.
“Tankyrase sits in the nexus of several known cancer pathways. These studies have helped us discern its role and have opened the door to a whole new area in how information is processed in cells that was previously obscure. We have furthered our understanding of how genes that control development often control cancer,” says Dr. Rottapel.
He adds: “This is how research happens; following unanticipated opportunities that unveil connectivity that teaches us about the general pathways that lead to human disease.”
This research was funded by the Terry Fox Research Institute, the Canadian Cancer Society Research Institute, The Princess Margaret Hospital Foundation, the Ontario Ministry of Health and Long-term Care, the Arthritis Centre for Excellence Fellowship, of T, the National Institutes of Health and the Charles H. Hood Foundation Inc., Boston.
Princess Margaret Hospital and Ontario Cancer Institute, the hospital’s research arm, have achieved an international reputation as global leaders in the fight against cancer. Princess Margaret Hospital is a member of the University Health Network, which also includes Toronto General Hospital, Toronto Western Hospital and Toronto Rehabilitation Institute. All are research hospitals affiliated with the University of Toronto. For more information, go to www.uhn.caMedia contact:
Jane Finlayson | Newswise Science News
Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH
Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences