Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cancer-Related Pathway Reveals Potential Treatment Target for Rare Pediatric Disease

09.12.2011
Cancer researchers studying genetic mutations that cause leukemia have discovered a connection to the rare disease cherubism, an inherited facial bone disorder in children.

The link is the enzyme Tankyrase and its pivotal role in switching on or off the protein that controls two known cancer genes. In normal cells, the protein is vital for bone development. In abnormal cells, it is thought to be involved in two common types of blood cancer – chronic myelogenous leukemia and acute myeloid leukemia.

The findings, published online today in CELL (DOI: 10.1016/j.cell.2011.10.046), zero in on how the enzyme alters the protein 3BP2, says principal investigator Dr. Robert Rottapel, clinician-scientist at The Campbell Family Institute for Cancer Research in the Princess Margaret Cancer Program, University Health Network and St. Michael’s Hospital. He is also a Professor, Faculty of Medicine, University of Toronto, and holds the Amgen Chair for Cancer Research.

“We have defined the rules of engagement for Tankyrase, which clearly identifies a potential target for developing therapeutic agents for human disease,” says Dr. Rottapel. These studies point the way for new therapeutic approaches in treating cherubism, using inhibitors that are already available in the clinic.

In a separate but related study (also published today) co-led by Dr. Rottapel and Dr. Frank Sicheri at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, the investigators further defined the structural details that define the interaction between Tankyrase and 3BP2.

“Tankyrase sits in the nexus of several known cancer pathways. These studies have helped us discern its role and have opened the door to a whole new area in how information is processed in cells that was previously obscure. We have furthered our understanding of how genes that control development often control cancer,” says Dr. Rottapel.

He adds: “This is how research happens; following unanticipated opportunities that unveil connectivity that teaches us about the general pathways that lead to human disease.”

This research was funded by the Terry Fox Research Institute, the Canadian Cancer Society Research Institute, The Princess Margaret Hospital Foundation, the Ontario Ministry of Health and Long-term Care, the Arthritis Centre for Excellence Fellowship, of T, the National Institutes of Health and the Charles H. Hood Foundation Inc., Boston.

Princess Margaret Hospital and Ontario Cancer Institute, the hospital’s research arm, have achieved an international reputation as global leaders in the fight against cancer. Princess Margaret Hospital is a member of the University Health Network, which also includes Toronto General Hospital, Toronto Western Hospital and Toronto Rehabilitation Institute. All are research hospitals affiliated with the University of Toronto. For more information, go to www.uhn.ca

Media contact:
Jane Finlayson, Public Affairs, 416-946-284
jane.finlayson@uhn.ca

Jane Finlayson | Newswise Science News
Further information:
http://www.uhn.ca

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>