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Cajal-Retzius cell loss and amyloidosis in Alzheimer's disease


Cajal-Retzius cells are reelin-secreting neurons in the marginal zone of the neocortex and hippocampus.

However, the relationship between Cajal-Retzius cells and Alzheimer's disease is unknown.

Cajal-Retzius cells were observed in the molecular layer of the dentate gyrus as early as embryonic day 16.5, and were densely concentrated in the molecular layer of the dentate gyrus (immunohistochemical analysis).

Credit: Neural Regeneration Research

Dr. Jinbo Deng and team from Henan University in China revealed that the number of Cajal-Retzius cells markedly reduced with age in both wild type and in mice over-expressing the Swedish double mutant form of amyloid precursor protein 695 (transgenic (Tg) 2576 mice).

The decline in Cajal-Retzius cells in Tg2576 mice was found to occur concomitantly with the onset of Alzheimer's disease amyloid pathology and related behavioral defcits.

Overall, these data, published in the Neural Regeneration Research (Vol. 9, No. 4, 2014), indicated that Cajal-Retzius cell loss occurred with the onset and development of Alzheimer's disease.


Article: " Characterization of hippocampal Cajal-Retzius cells during development in a mouse model of Alzheimer's disease (Tg2576)," by Dongming Yu1, Wenjuan Fan2, Ping Wu1, Jiexin Deng1, Jing Liu1, Yanli Niu1, Mingshan Li1, Jinbo Deng1 (1 Institute of Neurobiology, School of Life Science, Henan University, Kaifeng, Henan Province, China; 2 Laboratory of Molecular Medicine, Luohe Medical College, Luohe, Henan Province, China)

Yu DM, Fan WJ, Wu P, Deng JX, Liu J, Niu YL, Li MS, Deng JB. Characterization of hippocampal Cajal-Retzius cells during development in a mouse model of Alzheimer's disease (Tg2576). Neural Regen Res. 2014;9(4):394-401.


Meng Zhao
Neural Regeneration Research

Meng Zhao | Eurek Alert!

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