Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cajal-Retzius cell loss and amyloidosis in Alzheimer's disease

06.05.2014

Cajal-Retzius cells are reelin-secreting neurons in the marginal zone of the neocortex and hippocampus.


Cajal-Retzius cells were observed in the molecular layer of the dentate gyrus as early as embryonic day 16.5, and were densely concentrated in the molecular layer of the dentate gyrus (immunohistochemical analysis).

Credit: Neural Regeneration Research

However, the relationship between Cajal-Retzius cells and Alzheimer's disease is unknown.

Dr. Jinbo Deng and team from Henan University in China revealed that the number of Cajal-Retzius cells markedly reduced with age in both wild type and in mice over-expressing the Swedish double mutant form of amyloid precursor protein 695 (transgenic (Tg) 2576 mice).

The decline in Cajal-Retzius cells in Tg2576 mice was found to occur concomitantly with the onset of Alzheimer's disease amyloid pathology and related behavioral defcits.

Overall, these data, published in the Neural Regeneration Research (Vol. 9, No. 4, 2014), indicated that Cajal-Retzius cell loss occurred with the onset and development of Alzheimer's disease.

###

Article: " Characterization of hippocampal Cajal-Retzius cells during development in a mouse model of Alzheimer's disease (Tg2576)," by Dongming Yu1, Wenjuan Fan2, Ping Wu1, Jiexin Deng1, Jing Liu1, Yanli Niu1, Mingshan Li1, Jinbo Deng1 (1 Institute of Neurobiology, School of Life Science, Henan University, Kaifeng, Henan Province, China; 2 Laboratory of Molecular Medicine, Luohe Medical College, Luohe, Henan Province, China)

Yu DM, Fan WJ, Wu P, Deng JX, Liu J, Niu YL, Li MS, Deng JB. Characterization of hippocampal Cajal-Retzius cells during development in a mouse model of Alzheimer's disease (Tg2576). Neural Regen Res. 2014;9(4):394-401.

Contact:

Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/

Meng Zhao | Eurek Alert!

More articles from Life Sciences:

nachricht Female bonobos start up early
28.07.2014 | Max Planck Institute for Evolutionary Anthropology, Leipzig

nachricht Pump! And you will grow
28.07.2014 | Max-Planck-Institut für Molekulare Pflanzenphysiologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

9th European Wood-Based Panel Symposium 2014 – meeting point for the wood-based material branch

24.07.2014 | Event News

“Lens on Life” - Artists and Scientists Explore Cell Divison

08.07.2014 | Event News

First International Conference on Consumer Research | ICCR 2014: Early bird deadline July 31, 2014

08.07.2014 | Event News

 
Latest News

Female bonobos start up early

28.07.2014 | Life Sciences

First national study finds trees saving lives, reducing respiratory problems

28.07.2014 | Health and Medicine

Kidney transplant drug halves the early risk of rejection and allows less toxic treatment

28.07.2014 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>