Cajal-Retzius cells are reelin-secreting neurons in the marginal zone of the neocortex and hippocampus.
However, the relationship between Cajal-Retzius cells and Alzheimer's disease is unknown.
Dr. Jinbo Deng and team from Henan University in China revealed that the number of Cajal-Retzius cells markedly reduced with age in both wild type and in mice over-expressing the Swedish double mutant form of amyloid precursor protein 695 (transgenic (Tg) 2576 mice).
The decline in Cajal-Retzius cells in Tg2576 mice was found to occur concomitantly with the onset of Alzheimer's disease amyloid pathology and related behavioral defcits.
Overall, these data, published in the Neural Regeneration Research (Vol. 9, No. 4, 2014), indicated that Cajal-Retzius cell loss occurred with the onset and development of Alzheimer's disease.
Article: " Characterization of hippocampal Cajal-Retzius cells during development in a mouse model of Alzheimer's disease (Tg2576)," by Dongming Yu1, Wenjuan Fan2, Ping Wu1, Jiexin Deng1, Jing Liu1, Yanli Niu1, Mingshan Li1, Jinbo Deng1 (1 Institute of Neurobiology, School of Life Science, Henan University, Kaifeng, Henan Province, China; 2 Laboratory of Molecular Medicine, Luohe Medical College, Luohe, Henan Province, China)
Yu DM, Fan WJ, Wu P, Deng JX, Liu J, Niu YL, Li MS, Deng JB. Characterization of hippocampal Cajal-Retzius cells during development in a mouse model of Alzheimer's disease (Tg2576). Neural Regen Res. 2014;9(4):394-401.
Meng Zhao | Eurek Alert!
Fruit fly studies shed light on adaptability of nerve cells
17.04.2015 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)
Rare monkey photographed in Congo's newest national park, Ntokou-Pikounda
17.04.2015 | Wildlife Conservation Society
Astronomers from Chalmers University of Technology have used the giant telescope Alma to reveal an extremely powerful magnetic field very close to a supermassive black hole in a distant galaxy
Astronomers from Chalmers University of Technology have used the giant telescope Alma to reveal an extremely powerful magnetic field very close to a...
A team of physicists from MPQ, Caltech, and ICFO proposes the combination of nano-photonics with ultracold atoms for simulating quantum many-body systems and creating new states of matter.
Ultracold atoms in the so-called optical lattices, that are generated by crosswise superposition of laser beams, have been proven to be one of the most...
According to new research out of the Texas A&M Health Science Center College of Medicine, that is indeed the case. Chetan Jinadatha, M.D., M.P.H., assistant...
Researchers from ICFO, MIT and UC Riverside have been able to develop a graphene-based photodetector capable of converting absorbed light into an electrical voltage at ultrafast timescales
The efficient conversion of light into electricity plays a crucial role in many technologies, ranging from cameras to solar cells.
Electrical charges not only move through wires, they also travel along lengths of DNA, the molecule of life. The property is known as charge transport.
In a new study appearing in the journal Nature Chemistry, authors, Limin Xiang, Julio Palma, Christopher Bruot and others at Arizona State University's...
13.04.2015 | Event News
25.03.2015 | Event News
19.03.2015 | Event News
17.04.2015 | Power and Electrical Engineering
17.04.2015 | Earth Sciences
17.04.2015 | Physics and Astronomy