Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

BUSM researchers identify key regulator of inflammatory response

13.04.2012
Researchers at Boston University School of Medicine (BUSM) have identified a gene that plays a key role in regulating inflammatory response and homeostasis. These findings could help lead to the development of innovative methods to reduce the inflammation associated with cancer, type 2 diabetes and other diseases.

The study, which was led by Valentina Perissi, PhD, assistant professor of biochemistry at BUSM, was done in collaboration with the Howard Hughes Medical Institute (HHMI) at the University of California, San Diego. The results are published online and will be in the April 13 print issue of Molecular Cell.

Cells respond to inflammation by producing cytokines, which are cellular signaling protein molecules that allow for intercellular communication. Cytokines, such as TNF-alpha for example, bind to specific receptors on cellular membranes, activating an intracellular signaling process.

In this study, researchers looked at a gene called GPS2, which was previously known to regulate gene expression in the nucleus. This study found that GPS2 plays a critical role at the cellular membrane level to negatively regulate the signaling cascade activated by TNF-alpha. As a result, they observed that increasing GPS2 levels was sufficient to impair the response to TNF-alpha, resulting in a decreased inflammatory response.

Given this information, the researchers then examined whether having more GPS2 in fat tissue would help reduce the development of insulin resistance in conjunction with obesity. The results were promising as insulin signaling in the fat tissue was greatly improved. However, overexpression of GPS2 in the nucleus also had a negative effect on liver function.

"Our study demonstrates that GPS2 plays an important regulatory function in mitigating inflammation," said Perissi, who served as the study's senior author. "These findings have uncovered a potential new target for therapeutic treatments against diseases such as type 2 diabetes and metabolic syndrome, but more research needs to be done to better understand how GPS2 is regulated and whether we can specifically target its anti-inflammatory role."

Funding for this study was provided by HHMI, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Susan G. Komen Foundation.

Jenny Eriksen | EurekAlert!
Further information:
http://www.bmc.org

More articles from Life Sciences:

nachricht Fingerprint' technique spots frog populations at risk from pollution
27.03.2017 | Lancaster University

nachricht Parallel computation provides deeper insight into brain function
27.03.2017 | Okinawa Institute of Science and Technology (OIST) Graduate University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Northern oceans pumped CO2 into the atmosphere

27.03.2017 | Earth Sciences

Fingerprint' technique spots frog populations at risk from pollution

27.03.2017 | Life Sciences

Big data approach to predict protein structure

27.03.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>