Building on observations that rapamycin extends healthy lifespan in various species (Kaeberlein & Kennedy; Nature 2009), the collaborators will evaluate rapamycin analogs and other polyketides in a broad range of age-related disease models to identify novel therapeutics.
“We welcome this collaboration with Biotica with great enthusiasm. Their polyketides represent some of the most novel and promising drug leads for the development of therapeutics for age-related disease,” said Buck Institute CEO and President Brian Kennedy, PhD, who added that several Buck laboratories will be involved in the screening process. “We look forward to working with Biotica to move potential therapeutics toward commercialization. We have great respect for the company and their technology - the fact that we will both benefit from commercialization of new discoveries is a harbinger of great things to come.”
“Prof. Kennedy and the Buck Institute are recognized as leaders in research on aging, and have played a key role in identifying the life-extending properties of rapamycin,” commented Barrie Wilkinson, PhD, Biotica’s VP of Research. “We’re extremely fortunate to be working with the Buck’s outstanding investigators, and to have access to their diverse range of scientific approaches to age-related disease.”
The collaboration builds upon an existing relationship between Prof. Kennedy and Biotica, studying longevity-enhancing properties of non-rapamycin polyketides. The recent return of Biotica’s rapamycin analog program from Pfizer, in August 2011, has created an opportunity to add value in addition to its current focus on multiple sclerosis (MS) and systemic lupus erythematosus (SLE). In addition to the work on rapamycin analogs, the collaborators expect to identify new polyketides with therapeutic potential in age-related disease.About the Buck Institute for Research on Aging
Kris Rebillot | Newswise Science News
Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory
How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
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24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy