Would you want to swallow a tablet that’s yellow rather than its usual white? Would this effect be harmless and would the drug still be efficient?
Researchers in India have now described an approach to maintaining the color and activity of an antitumor agent. As they report in Chemistry - An Asian Journal, acids can protect powders of the drug from discoloration and loss of activity.
The anticancer agent temozolomide is stable in the presence of acid, but when white tablets of the drug are stored for an extended period of time, they turn light pink or tan. This discoloration is indicative of degradation by water in neutral or basic conditions, which lowers the effectiveness of the drug, and has the potential to disconcert patients.
Ashwini Nangia and co-workers at the University of Hyderabad, India, have developed a method to increase the chemical stability of temozolomide and prevent discoloration. They made solids comprising temozolomide that is intimately mixed with an acid, forming so-called cocrystals.
The acid effectively protects the drug from degradation, and the cocrystals showed no signs of discoloration for over six months, even in humid air. As acids, they chose safe organic acids such as acetic acid (found in vinegar), succinic acid (a fermentation byproduct) and oxalic acid (found in rhubarb). Preliminary assessment of the pharmacological properties of the cocrystals indicates that especially those incorporating succinic acid and oxalic acid could be suitable for use in formulation development.Author: Ashwini Nangia, University of Hyderabad, India, http://188.8.131.52/~an/
Title: Crystal Engineering of Stable Temozolomide Cocrystals
Chemistry - An Asian Journal, Permalink to the article: http://dx.doi.org/10.1002/asia.201200205
Ashwini Nangia | Wiley-VCH
Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory
How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy