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Breakthrough Research Could Create Sea Change in Global HIV Diagnosis

New Handheld Mobile Device Performs Laboratory-Quality HIV Testing

New research appearing online today in Clinical Chemistry, the journal of AACC, shows that a handheld mobile device can check patients’ HIV status with just a finger prick, and synchronize the results in real time with electronic health records. This technology takes a step toward providing remote areas of the world with diagnostic services traditionally available only in centralized healthcare settings.

Of the 34 million people infected with HIV worldwide, 68% of them live in sub-Saharan Africa, with South and Southeast Asia bearing the second greatest burden of disease. Many HIV-infected people in these regions are unable to get tested or treated because they can’t easily travel to centralized healthcare centers. This creates an extreme economic burden on already-poor nations, with the epidemic estimated to cause a 1.5% annual loss in gross domestic product each year for the worst-affected countries. It has also created 16.6 million AIDS orphans—children who have lost one or both parents to the disease.

A low-cost mobile device that performs HIV testing could help combat these trends, and the overall global epidemic, by enabling the diagnosis and treatment of HIV-infected people in resource-limited settings. In this study, a team including Curtis D. Chin, PhD, and Yuk Kee Cheung, PhD, designed a device that captures all the essential functions of enzyme-linked immunosorbent assays, the most commonly used laboratory diagnostic for HIV. The authors show that the device performs laboratory-quality HIV testing in 15 minutes using finger-pricked whole blood.

The device also detects weakly positive samples, and uses cellphone and satellite networks to automatically synchronize test results with patient health records from anywhere in the world. Because of this real-time data upload, this mobile device will allow policymakers and epidemiologists to monitor disease prevalence across geographical regions quickly and effectively. This could improve effectiveness in allocating medications to different communities, and patient care in general.

Dr. Nader Rifai, editor in chief of Clinical Chemistry, states, "This is a perfect example of how ingenuity and good science can effectively address a real and serious medical problem."

About AACC
The American Association for Clinical Chemistry, AACC, is a leading international medical society dedicated to improving healthcare through laboratory medicine. With more than 9,000 clinical laboratory professionals, physicians, research scientists, and other members involved in developing tests and directing laboratory operations, AACC brings the laboratory community together with programs that advance knowledge, expertise, and innovation.

Clinical Chemistry is the leading international journal of clinical laboratory science, providing 2,000 pages per year of peer-reviewed papers that advance the science of the field. With an impact factor of 7.9, Clinical Chemistry covers everything from molecular diagnostics to laboratory management.

Molly Polen | Newswise
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