Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Brandeis inventor patents anti-cholesterol formula

19.06.2013
Daniel Perlman '68 solves phytosterol dispersability problem

Senior Brandeis research scientist Daniel Perlman ’68 has discovered a way to make phytosterol molecules from plants dispersible in beverages and foods that are consumed by humans, potentially opening the way to dramatic reductions in human cholesterol levels.

A U.S. patent (number 8,460,738) on the new process and composition was issued on June 11.

Phytosterols in plants and cholesterol molecules in animals are highly similar and when both are dispersed together they are attracted to one another. When they mix in the gut of an animal, the cholesterol molecules are competitively inhibited from passing into the blood stream and instead are excreted.
The ability of phytosterols to reduce cholesterol levels in animals has been recognized since the 1950s, but practical application of this knowledge was difficult because phytosterols are not naturally water-soluble, and they are only poorly soluble in fatty substances.

Perlman and K.C. Hayes, professor emeritus of biology and former director of the Foster Biomedical Research Laboratories, invented and patented a way to increase the bioavailability of phytosterols in fats more than 10 years ago. Their separate discoveries relating to fat metabolism and oxidative stability led to development of the Smart Balance blend of oils and a number of other food products.

However, improving dispersal of phytosterols in water has remained problematic, and was an obstacle to their general use in foods and beverages. Phytosterols placed in water-based substances will not disperse, and this has thwarted their cholesterol-reducing potential.

Now, Perlman has found a way to change the behavior of phytosterols in liquids by forming a new complex in which glycerin molecules attach to phytosterol molecules. Phytosterols and glycerin are heated together to a temperature at which the water molecule that usually attaches to each phytosterol molecule boils off and is replaced by a glycerin molecule. Because glycerin molecules have multiple places at which water molecules can be attached and because glycerin also inhibits crystal growth that complicates dispersal, the phytosterol-glycerin complex together with an emulsifier becomes dispersible in water-based foods.

“I had been playing with ideas on how to enhance the dispersability of this molecule for a number of years,” said Perlman, who has more than 100 patents and pending patents on inventions he has made in his years at Brandeis. This was critically important, he explained, because “if you really want to have widespread public health benefits, you want to be able to put [phytosterols] in foods and beverages.”

Hayes said he has tested Perlman’s new compound in his laboratory for its effects on lipoprotein metabolism with excellent results in terms of its cholesterol-reducing action.

Physics Professor Seth Fraden, who is director of the Brandeis Materials Research Science and Engineering Center, said “the actual science of how it all works” when the attachment of glycerin changes phytosterol behavior “is not understood.”

Perlman, he said, “had a chemical intuition for doing this. He is a good chemist; he has a feeling for molecules and what they’ll do when you mix them. In addition to this intuition, he is very open-minded and will go in the lab and try things that other people don’t do because their professors have told them it won’t work.

“That’s why he’s a good inventor,” Fraden said.

Charles A. Radin | EurekAlert!
Further information:
http://www.brandeis.edu

More articles from Life Sciences:

nachricht One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie

nachricht The dark side of cichlid fish: from cannibal to caregiver
20.04.2018 | Veterinärmedizinische Universität Wien

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Magnetic nano-imaging on a table top

20.04.2018 | Physics and Astronomy

Start of work for the world's largest electric truck

20.04.2018 | Interdisciplinary Research

Atoms may hum a tune from grand cosmic symphony

20.04.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>