Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Brain mapping reveals neurological basis of decision-making in rats

21.03.2013
Scientists at UC San Francisco have discovered how memory recall is linked to decision-making in rats, showing that measurable activity in one part of the brain occurs when rats in a maze are playing out memories that help them decide which way to turn. The more they play out these memories, the more likely they are to find their way correctly to the end of the maze.

In their study, reported this week in the journal Neuron, the UCSF researchers implanted electrodes directly on a region of the rat brain known as the hippocampus, which is already known to play a key role in the formation and recall of memory. This same region is active when animals are learning, and it is damaged in people who have Alzheimer's and post-traumatic stress disorder.

The study showed that when the rats paused before an upcoming choice, sometimes the hippocampus was more active and sometimes it was less active. When it was more active it did a better job of recalling memories of places the animal could go next, and the animal was more likely to go to the right place.

"We know that considering possibilities is important for decision-making, but we haven't really known how this happens in the brain," said neuroscientist Loren Frank, PhD, who led the research. Frank is an associate professor of physiology and a member of the UCSF Center for Integrative Neuroscience at UCSF.

The work builds upon several years of investigations in Frank's laboratory that have shown how activity in the hippocampus is a fundamental constituent of memory retrieval. Their recent work shows that this activity is not just about remembering the past – it is also important for thinking about the future. When the brain does a better job of thinking about future possibilities, it makes better decisions.

Next, the team wants to tease out why sometimes the hippocampus does not do a good job of playing out future options. Problems with memory and decision-making are central to age-related cognitive decline, and a deeper understanding of how this works could pave the way for interventions that make the brain work better.

The article, "Hippocampal SWR Activity Predicts Correct Decisions during the Initial Learning of an Alternation Task" is authored by Annabelle C. Singer, Margaret F. Carr, Mattias P. Karlsson, and Loren M. Frank. The work appears in the March 20, 2013 issue of the journal Neuron. After that date, the article can be accessed at: http://dx.doi.org/10.1016/j.neuron.2013.01.027

In addition to Dr. Frank, the other authors on the study are former graduate students from UCSF who are now, affiliated with the McGovern Institute for Brain Research and MIT Media Lab in Cambridge, MA; Stanford University; and the Howard Hughes Medical Institute's Janelia Farms Research Campus in Ashburn, VA.

This work was supported by the John Merck Scholars Program and the U.S. National Institutes of Health via grant #RO1MH090188 and #F31093067.

UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.

Jason Socrates Bardi | EurekAlert!
Further information:
http://www.ucsf.edu

More articles from Life Sciences:

nachricht A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht On the way to developing a new active ingredient against chronic infections
21.08.2017 | Deutsches Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Heating quantum matter: A novel view on topology

22.08.2017 | Physics and Astronomy

Stretchable biofuel cells extract energy from sweat to power wearable devices

22.08.2017 | Power and Electrical Engineering

New technique to treating mitral valve diseases: First patient data

22.08.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>