Nutritional supplementation with Spirulina, a nutrient-rich, blue-green algae, appeared to provide neuroprotective support for dying motor neurons in a mouse model of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, University of South Florida neuroscientists have found. Although more research is needed, they suggest that a spirulina-supplemented diet may provide clinical benefits for ALS patients.
A spirulina dietary supplement was shown to delay the onset of motor symptoms and disease progression, reducing inflammatory markers and motor neuron death in a G93A mouse model of ALS. Spirulina, an ancient food source used by the Aztecs, may have a dual antioxidant and anti-inflammatory effect on motor neurons, the researchers said.
Their study is published in the current issue of The Open Tissue Engineering and Regenerative Medicine Journal (3:36-41).
"ALS is a degenerative motor neuron disease," said the study's lead author, Svitlana Garbuzova-Davis, PhD, DSc, assistant professor in the Department of Neurosurgery and Brain Repair at USF. "Most available treatments relieve symptoms without altering the underlying disease. However, evidence for oxidative stress has been associated with ALS and, in our past studies, we demonstrated potent decreases in markers of oxidative damage and inflammation in aged rats fed diets supplemented with spirulina or spinach. In this initial study, the diet supplement was fed only to pre-symptomatic mice. Further studies showing the diet supplement's effect on the lifespan of symptomatic ALS mice are needed to prove the treatment's effectiveness."
Specifically, when the USF researchers tested compounds found in blueberries and spirulina for effectiveness in animal models of stroke and aging in past experiments, they noted neuroprotective effects of the nutritional supplements.
The current study compared ALS mice receiving a spirulina-supplemented diet over a 10-week period with mice that did not receive the diet supplementation. The spirulina-fed ALS mice showed reduced inflammatory markers and motor neuron degeneration over that period.
"The focus of our future ALS experiments will include motor neuron counts and an examination of lifespan following dietary spirulina supplementation in symptomatic ALS mice," said study co-author Paula C. Bickford, PhD, a professor in the USF Department of Neurosurgery and Brain Repair and a senior research biologist at the James A. Haley Veterans' Hospital in Tampa, Florida.
- USF Health -
USF Health (www.health.usf.edu) is dedicated to creating a model of health care based on understanding the full spectrum of health. It includes the University of South Florida's colleges of medicine, nursing, pharmacy and public health; the schools of biomedical sciences as well physical therapy & rehabilitation sciences; and the USF Physicians Group. With more than $394.1 million in research grants and contracts in FY2009/2010, the University of South Florida is one of the nation's top 63 public research universities and one of only 25 public research universities nationwide with very high research activity that is designated as community-engaged by the Carnegie Foundation for the Advancement of Teaching.
Randolph Fillmore | EurekAlert!
Tag it EASI – a new method for accurate protein analysis
19.06.2018 | Max-Planck-Institut für Biochemie
How to track and trace a protein: Nanosensors monitor intracellular deliveries
19.06.2018 | Universität Basel
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
19.06.2018 | Physics and Astronomy
19.06.2018 | Life Sciences
19.06.2018 | Physics and Astronomy