This means that such blood samples could be used to predict the development of the disease and thereby make it possible to prevent the pathological process, according to an article by Umeå researcher Solbritt Rantapää-Dahlqvist and her associates in the journal Arthritis and Rheumatism.
The research team analyzed blood samples from 86 individuals who donated samples to the Medical Biobank before they developed arthritic rheumatism. Of these, 69 had submitted samples at the time they were developing the disease.
Moreover, blood samples were analyzed from 256 population-based matched controls from the Medical Biobank. The concentrations of 30 different cytokines and cytokine-related factors in plasma were measured using a so-called multiplex system.
The results show that individuals that later developed arthritic rheumatism had significantly elevated levels of most cytokines and that these cytokine patterns distinguished them from the control individuals. There was a connection with several different parts of the immune defense and also with specific auto-antibodies, so-called anti-cyclic citrullinated peptide antibodies. The results indicate that several years before individuals develop symptoms of arthritic rheumatism, the immune system is activated and the process that leads to arthritic rheumatism has started.
"Our findings point to the possibility of better predicting the development of arthritic rheumatism and perhaps also of preventing the development of the disease," says Solbritt Rantapää-Dahlqvist.
Arthritic rheumatism is a chronic autoimmune disorder characterized by joint inflammation that ultimately leads to the breakdown of cartilage and bone. The disease is difficult to diagnose early since its symptoms can often be diffuse at first. However, studies have shown that it is important to diagnose and treat the disease early in order to prevent severe joint damage.
Phone: +46 (0)90-785 17 29, e-mail: email@example.com
Pressofficer Bertil Born;firstname.lastname@example.org; +46-70388 60 58Reference:
Bertil Born | idw
New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg
Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
24.02.2017 | Life Sciences
24.02.2017 | Life Sciences
24.02.2017 | Trade Fair News