The findings, published online last week in the American Journal of Respiratory and Critical Care Medicine, could help doctors determine those patients in imminent need of a lung transplant and those who can wait a while longer.
Fifty percent of IPF patients die within three years of diagnosis, but others will do well for long periods of time, explained investigator Naftali Kaminski, M.D., professor of medicine, pathology, human genetics and computational biology, Pitt School of Medicine, and director, The Dorothy P. & Richard P. Simmons Center for Interstitial Lung Disease at UPMC. In the disease, breathing becomes increasingly impaired as the lungs progressively scar.
"It's hard to tell based on symptoms alone which patients are in the greatest danger," Dr. Kaminski said. "This biomarker panel has predictive power that can guide our treatment plan. It may also help us design more effective research trials because we'll be able to better match experimental therapies with the most appropriate patients."
The research team collected blood samples from 241 IPF patients. They measured the levels of 92 candidate proteins in 140 patients and found that higher concentrations of five particular proteins that are produced by the breakdown of lung tissue predicted poor survival, transplant-free survival and progression-free survival regardless of age, sex and baseline pulmonary function. They then confirmed the results in a second group of 101 patients.
Based on both groups, the investigators developed the personal clinical and molecular mortality prediction index (PCMI) that incorporates the gender, lung functions and levels of one of the proteins, called MMP7, in the blood. Patients with a low PCMI were more likely to live more than 5 years while the median survival for patients with high PCMI scores was 1.5 years.
"This indicates that these blood biomarker levels are not just a reflection of current severity of the lung disease, but they are predictive of impending death," said lead author Thomas Richards, Ph.D., assistant professor of medicine and head of the Simmons Center biostatistics team.
"They have the potential to greatly improve our treatment strategies for IPF, in part by showing us which patients have the most urgent need for lung transplant, which is currently the only cure for the disease," added senior author Kevin Gibson, M.D., medical director of the Simmons Center.
"These findings provide proof of the concept of personalized medicine. " noted Mark T. Gladwin, M.D., chief, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine. "We can use a combination of biological and clinical markers to determine the very best care for each patient.
Drs. Kaminski, Gibson and colleagues have research projects underway to better understand how the biomarkers change over time.
The team includes Kathleen O. Lindell, Ph.D., R.N., and others at the Simmons Center and Pitt School of Medicine, as well as researchers from Centocor R & D in Radnor, Pa.
Study results will be presented by Dr. Kaminski at the IPF session of the Pittsburgh International Lung Conference on Personalized Medicine of Lung Disease at 2:30 p.m. on October 28 and 29 at the Holiday Inn Pittsburgh University Center.
The project was funded by the National Institutes of Health, Centocor, and the Dorothy P. and Richard P. Simmons Endowed Chair for Pulmonary Research.
About the University of Pittsburgh School of Medicine
As one of the nation's leading academic centers for biomedical research, the University of Pittsburgh School of Medicine integrates advanced technology with basic science across a broad range of disciplines in a continuous quest to harness the power of new knowledge and improve the human condition. Driven mainly by the School of Medicine and its affiliates, Pitt has ranked among the top 10 recipients of funding from the National Institutes of Health since 1997.
Likewise, the School of Medicine is equally committed to advancing the quality and strength of its medical and graduate education programs, for which it is recognized as an innovative leader, and to training highly skilled, compassionate clinicians and creative scientists well-equipped to engage in world-class research. The School of Medicine is the academic partner of UPMC, which has collaborated with the University to raise the standard of medical excellence in Pittsburgh and to position health care as a driving force behind the region's economy. For more information about the School of Medicine, see www.medschool.pitt.edu.
Anita Srikameswaran | EurekAlert!
Link Discovered between Immune System, Brain Structure and Memory
26.04.2017 | Universität Basel
Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
26.04.2017 | Materials Sciences
26.04.2017 | Agricultural and Forestry Science
26.04.2017 | Physics and Astronomy