Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Blood and lymphatic capillaries grown for the first time in the lab

30.01.2014
Researchers at the University Children’s Hospital Zurich and the University of Zurich have engineered skin cells for the very first time containing blood and lymphatic capillaries. They succeeded in isolating all the necessary types of skin cells from human skin tissue and engineering a skin graft that is similar to full-thickness skin.

Every year around 11 million people suffer severe burns. The resulting large, deep wounds caused by burning only heal slowly; this results in lifelong scars. What is needed to reduce this kind of scarring is the grafting of functional full-thickness skin.

Only a very limited area of skin can be removed from the individual patient as the surgery, in turn, creates new wounds. Besides conventional skin grafting, another option is to engineer a skin graft in the lab which firstly is composed of the patient’s cells and secondly is very similar to natural human skin.

Up to now these complex skin grafts didn’t contain any blood or lymphatic capillaries, pigmentation, sebaceous glands, hair follicles or nerves. The researchers at the Tissue Biology Research Unit, the research department of the Surgical Clinic and at the Research Centre for Children at the University Children’s Hospital Zurich have been engineering dermo-epidermal skin grafts for some time but now they have succeeded in constructing a more complex organ. “We were able to isolate all the necessary skin cells from a human skin sample and to engineer a skin graft similar to full-thickness skin that contains for the first time blood and lymphatic capillaries too”, says Martin Meuli, Head of the Surgical Clinic at the University Children’s Hospital Zurich.

Fully functional lymphatic capillaries generated for the first time
Tissue fluid is excreted from a wound which accumulates in a cavity on the skin’s surface and can impede wound healing. Lymphatic vessels drain off this fluid. The researchers isolated lymphatic capillary cells from the human dermis. Together with the blood capillaries that were also engineered, this guarantees rapid, efficient vesicular supply of the skin graft. Up to now, this had been a major unsolved problem in molecular tissue biology and regenerative medicine.

The scientists in the team of Ernst Reichmann, Head of the Tissue Biology Research Unit, were surprised by three findings. The individual lymphatic cells spontaneously arranged themselves into lymphatic capillaries with all the characteristics of lymphatic vessels. In preclinical trials both the human lymphatic capillaries and the blood capillaries engineered in the laboratory connected with those of the laboratory animals. “What’s novel is that the lymphatic capillaries collected and transported tissue fluid; hence they were functional”, explains Ernst Reichmann and goes on to add, “We assume that skin grafts with lymphatic and blood capillaries will, in future, both prevent the accumulation of tissue fluid and ensure rapid blood supply of the graft”. This could markedly improve the healing process and the typical organ structure of this type of skin graft.

The first clinical application of these complex skin grafts is scheduled for 2014. They will not, however, contain any blood or lymphatic capillaries as approval has still to be obtained.

Literature:
Daniela Marino, Joachim Luginbühl, Simonetta Scola, Martin Meuli, Ernst Reichmann. Bioengineering Dermo-Epidermal Skin Grafts with Blood and Lymphatic Capillaries. Science Translational Medicine. January 29, 2104. DOI: 10.1126/scitranslmed.3006894

www.skingineering.ch

Contacts:
Professor Martin Meuli
Head Surgical Clinic
University Children’s Hospital Zurich
Tel. +41 44 266 80 23
Email: martin.meuli@kispi.uzh.ch
Professor Ernst Reichmann
Head Tissue Biology Research Unit
University Children’s Hospital Zurich
Tel. +41 44 6348911
Email: Ernst.Reichmann@kispi.uzh.ch

Nathalie Huber | Universität Zürich
Further information:
http://www.mediadesk.uzh.ch

More articles from Life Sciences:

nachricht Stress triggers key molecule to halt transcription of cell's genetic code
28.05.2015 | Stowers Institute for Medical Research

nachricht Chemists discover key reaction mechanism behind the highly touted sodium-oxygen battery
28.05.2015 | University of Waterloo

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Solid-state photonics goes extreme ultraviolet

Using ultrashort laser pulses, scientists in Max Planck Institute of Quantum Optics have demonstrated the emission of extreme ultraviolet radiation from thin dielectric films and have investigated the underlying mechanisms.

In 1961, only shortly after the invention of the first laser, scientists exposed silicon dioxide crystals (also known as quartz) to an intense ruby laser to...

Im Focus: Advance in regenerative medicine

The only professorship in Germany to date, one master's programme, one laboratory with worldwide unique equipment and the corresponding research results: The University of Würzburg is leading in the field of biofabrication.

Paul Dalton is presently the only professor of biofabrication in Germany. About a year ago, the Australian researcher relocated to the Würzburg department for...

Im Focus: Basel Physicists Develop Efficient Method of Signal Transmission from Nanocomponents

Physicists have developed an innovative method that could enable the efficient use of nanocomponents in electronic circuits. To achieve this, they have developed a layout in which a nanocomponent is connected to two electrical conductors, which uncouple the electrical signal in a highly efficient manner. The scientists at the Department of Physics and the Swiss Nanoscience Institute at the University of Basel have published their results in the scientific journal “Nature Communications” together with their colleagues from ETH Zurich.

Electronic components are becoming smaller and smaller. Components measuring just a few nanometers – the size of around ten atoms – are already being produced...

Im Focus: IoT-based Advanced Automobile Parking Navigation System

Development and implementation of an advanced automobile parking navigation platform for parking services

To fulfill the requirements of the industry, PolyU researchers developed the Advanced Automobile Parking Navigation Platform, which includes smart devices,...

Im Focus: First electrical car ferry in the world in operation in Norway now

  • Siemens delivers electric propulsion system and charging stations with lithium-ion batteries charged from hydro power
  • Ferry only uses 150 kilowatt hours (kWh) per route and reduces cost of fuel by 60 percent
  • Milestone on the road to operating emission-free ferries

The world's first electrical car and passenger ferry powered by batteries has entered service in Norway. The ferry only uses 150 kWh per route, which...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International symposium: trends in spatial analysis and modelling for a more sustainable land use

20.05.2015 | Event News

15th conference of the International Association of Colloid and Interface Scientists

18.05.2015 | Event News

EHFG 2015: Securing health in Europe. Balancing priorities, sharing responsibilities

12.05.2015 | Event News

 
Latest News

Siemens will provide the first H-class power plant technology in Mexico

28.05.2015 | Press release

Merging galaxies break radio silence

28.05.2015 | Physics and Astronomy

A New Kind of Wood Chip: Collaboration Could Yield Biodegradable Computer Chips

28.05.2015 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>