Every year around 11 million people suffer severe burns. The resulting large, deep wounds caused by burning only heal slowly; this results in lifelong scars. What is needed to reduce this kind of scarring is the grafting of functional full-thickness skin.
Only a very limited area of skin can be removed from the individual patient as the surgery, in turn, creates new wounds. Besides conventional skin grafting, another option is to engineer a skin graft in the lab which firstly is composed of the patient’s cells and secondly is very similar to natural human skin.
Up to now these complex skin grafts didn’t contain any blood or lymphatic capillaries, pigmentation, sebaceous glands, hair follicles or nerves. The researchers at the Tissue Biology Research Unit, the research department of the Surgical Clinic and at the Research Centre for Children at the University Children’s Hospital Zurich have been engineering dermo-epidermal skin grafts for some time but now they have succeeded in constructing a more complex organ. “We were able to isolate all the necessary skin cells from a human skin sample and to engineer a skin graft similar to full-thickness skin that contains for the first time blood and lymphatic capillaries too”, says Martin Meuli, Head of the Surgical Clinic at the University Children’s Hospital Zurich.
The scientists in the team of Ernst Reichmann, Head of the Tissue Biology Research Unit, were surprised by three findings. The individual lymphatic cells spontaneously arranged themselves into lymphatic capillaries with all the characteristics of lymphatic vessels. In preclinical trials both the human lymphatic capillaries and the blood capillaries engineered in the laboratory connected with those of the laboratory animals. “What’s novel is that the lymphatic capillaries collected and transported tissue fluid; hence they were functional”, explains Ernst Reichmann and goes on to add, “We assume that skin grafts with lymphatic and blood capillaries will, in future, both prevent the accumulation of tissue fluid and ensure rapid blood supply of the graft”. This could markedly improve the healing process and the typical organ structure of this type of skin graft.
The first clinical application of these complex skin grafts is scheduled for 2014. They will not, however, contain any blood or lymphatic capillaries as approval has still to be obtained.
Nathalie Huber | Universität Zürich
Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory
Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
09.12.2016 | Life Sciences
09.12.2016 | Ecology, The Environment and Conservation
09.12.2016 | Health and Medicine