Prof. Samuel Lo, Associate Head of the Department of Applied Biology and Chemical Technology, and Dr Derek Or, Associate Professor of the Department of Electrical Engineering, have jointly developed a Portable Real-time DNA Biosensor.
The device is designed to perform speedy in situ DNA tests for bio-defence and health surveillance purposes in areas suspected to be contaminated with pathogens and/or undesirable microbes.
Unlike conventional laboratory tests that take at least one or two days, this hand-held, battery-operated and fully automated biosensor is built upon a novel DNA-based bio-chemo-physical conversion method. It is able to detect harmful bacteria, such as E. coli, salmonella and staphylococcus, on site within 30 minutes. It can be adapted to cover such deadly viruses as SARS, H5N1 flu and swine flu viruses in future. It can also be re-designed to monitor possible biological attack from anthrax, smallpox and cholera etc.
Comprising a reaction chamber, an ultrasound core and an electronics power board, the new biosensor can test for the presence of a specific pathogen in water and air samples by recognizing the existence of its DNA. When this pathogen is added to the reaction chamber, the further addition of both specific primer-linked thrombin and fibrinogen triggers an innovative molecular bio-chemical reaction. In the case of a DNA primer match, the enzyme will convert fibrinogen into a lump of visible gel that blocks the transmission of ultrasound signals through the reaction chamber. A drop in the ultrasound reading is then a strong indicator of the presence of the target pathogen in the sample.
This invention won a Gold Award at the 39th International Exhibition of Inventions in Geneva, Switzerland.
This article was first appeared on PolyU Milestone, June 2011 edition.
Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University
Transfecting cells gently – the LZH presents a GNOME prototype at the Labvolution 2017
25.04.2017 | Laser Zentrum Hannover e.V.
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
25.04.2017 | Physics and Astronomy
25.04.2017 | Materials Sciences
25.04.2017 | Life Sciences