Prof. Samuel Lo, Associate Head of the Department of Applied Biology and Chemical Technology, and Dr Derek Or, Associate Professor of the Department of Electrical Engineering, have jointly developed a Portable Real-time DNA Biosensor.
The device is designed to perform speedy in situ DNA tests for bio-defence and health surveillance purposes in areas suspected to be contaminated with pathogens and/or undesirable microbes.
Unlike conventional laboratory tests that take at least one or two days, this hand-held, battery-operated and fully automated biosensor is built upon a novel DNA-based bio-chemo-physical conversion method. It is able to detect harmful bacteria, such as E. coli, salmonella and staphylococcus, on site within 30 minutes. It can be adapted to cover such deadly viruses as SARS, H5N1 flu and swine flu viruses in future. It can also be re-designed to monitor possible biological attack from anthrax, smallpox and cholera etc.
Comprising a reaction chamber, an ultrasound core and an electronics power board, the new biosensor can test for the presence of a specific pathogen in water and air samples by recognizing the existence of its DNA. When this pathogen is added to the reaction chamber, the further addition of both specific primer-linked thrombin and fibrinogen triggers an innovative molecular bio-chemical reaction. In the case of a DNA primer match, the enzyme will convert fibrinogen into a lump of visible gel that blocks the transmission of ultrasound signals through the reaction chamber. A drop in the ultrasound reading is then a strong indicator of the presence of the target pathogen in the sample.
This invention won a Gold Award at the 39th International Exhibition of Inventions in Geneva, Switzerland.
This article was first appeared on PolyU Milestone, June 2011 edition.
Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory
Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
09.12.2016 | Life Sciences
09.12.2016 | Ecology, The Environment and Conservation
09.12.2016 | Health and Medicine