This finding, the first of its kind and led by UC’s Bruce Yacyshyn, MD, is being presented via podium presentation by staff from Walter Reed National Military Medical Center at Digestive Disease Week 2013, being held May 18-21 in Orlando, Fla.
The DoDSR is a biological repository operated by the U.S. Department of Defense and contains over 50 million human serum specimens, collected primarily from applicants to and members of the U.S. uniformed services.
"With collaborators from Walter Reed, we were able to identify all of the active duty service men and women who developed IBD and then used the repository to go back and look at various biomarkers to see what each person had in common,” says Yacyshyn, a professor of medicine at the UC College of Medicine and UC Health gastroenterologist.
IBD is a group of inflammatory conditions of the colon and small intestine. The main types of IBD are Crohn's disease and ulcerative colitis; inflammatory bowel diseases are considered autoimmune diseases in which the body's own immune system attacks elements of the digestive system.
In this study, researchers used the repository to identify 50 cases of Crohn’s disease and 50 cases of ulcerative colitis. They analyzed proteins from three samples per case—two taken before and one after diagnosis—using a statistical analysis format.Certain proteins were found in elevated levels in samples from patients who developed IBD.
"The selection of proteins we chose to analyze was based on a prior study conducted at UC,” Yacyshyn says. "Although the presence of proteins in those who develop Crohn’s disease varies from those present in ulcerative colitis patients, we were able to show that there were elevated levels of certain proteins in patients who developed IBD.”
"Future large validation studies are needed to confirm the presence of biomarkers to guide in diagnosis, prevention and management of these patients,” he adds.
Yacyshyn and his collaborators in the division of digestive diseases and at Cincinnati Children’s Hospital Medical Center are hoping to study this further in a pediatric population and have requested funding from the Crohn’s and Colitis Foundation.
"This could change the way we currently screen for and treat IBD, which could improve prevention strategies, patient outcomes and their overall quality of life,” he says.
This study was investigator-initiated.
Katie Pence | EurekAlert!
A novel socio-ecological approach helps identifying suitable wolf habitats
17.02.2017 | Universität Zürich
New, ultra-flexible probes form reliable, scar-free integration with the brain
16.02.2017 | University of Texas at Austin
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
17.02.2017 | Medical Engineering
17.02.2017 | Medical Engineering
17.02.2017 | Health and Medicine