Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New biomarker may help diagnose ectopic pregnancies

04.11.2010
Novel serum test may help diagnose early pregnancy location and outcome

Researchers may have identified a promising novel diagnostic biomarker for ectopic pregnancy, according to a study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). In the western world, deaths from ectopic pregnancy are not common but in the developing world one in ten women who are admitted with an ectopic pregnancy die.

An ectopic pregnancy is an abnormal pregnancy that occurs outside the uterine cavity. Most ectopic pregnancies take place in the Fallopian tube but implantation can also occur in the cervix, ovaries and abdomen. Ectopic pregnancy is associated with severe pelvic pain and the need for a blood transfusion. The condition is a leading cause of pregnancy-related first trimester deaths.

"Finding a simple and cost-effective test using biomarkers to diagnose ectopic pregnancies would have a significant impact on reducing emotional distress and unnecessary deaths," said Andrew Horne, PhD, of the University of Edinburgh in the United Kingdom and lead author of the study. "Our study shows that placental growth factor (PIGF), a key molecule in the formation of blood vessels, is a promising novel diagnostic biomarker for ectopic pregnancies."

In this study, researchers obtained trophoblast samples from 40 pregnant women aged 18-45 years undergoing surgical termination of pregnancy, evacuation of uterus for embryonic missed miscarriage or surgery for tubal ectopic pregnancy. Trophoblasts are specialized cells of the placenta that play an important role in embryo implantation. Serum PIGF levels were measured in all trophoblast samples and researchers found that PIGF was reduced in samples from tubal ectopic pregnancies when compare to intrauterine pregnancies.

"The inevitable multiple visits and tests that are currently necessary to diagnose ectopic pregnancies are a sizable expense for health services," said Horne. "Serum PIGF may be the answer to the urgent unmet need for a biomarker for tubal ectopic pregnancy that allows quicker diagnosis and facilitates earlier and less invasive treatment. Large-scale studies are now required to determine its clinical utility."

Other researchers working on the study include: Julie Shaw, Amanda Murdoch, Sarah McDonald, Alistair Williams, Henry Jabbour, W. Colin Duncan and Hilary Critchley of the University of Edinburgh in the United Kingdom.

The article, "Placental growth factor: a promising diagnostic biomarker for tubal ectopic pregnancy," will appear in the January 2011 issue of JCEM.

Founded in 1916, The Endocrine Society is the world's oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, The Endocrine Society's membership consists of over 14,000 scientists, physicians, educators, nurses and students in more than 100 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Chevy Chase, Maryland. To learn more about the Society and the field of endocrinology, visit our site at www.endo-society.org

Aaron Lohr | EurekAlert!
Further information:
http://www.endo-society.org

More articles from Life Sciences:

nachricht Symbiotic bacteria: from hitchhiker to beetle bodyguard
28.04.2017 | Johannes Gutenberg-Universität Mainz

nachricht Nose2Brain – Better Therapy for Multiple Sclerosis
28.04.2017 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>