"This work determines part of the neural mechanism that mediates a conflict in a hungry fly's brain in deciding whether to seek food or sleep," said Scott Waddell, PhD, associate professor of neurobiology.
"It provides a foundation for understanding how the neural control of these two homeostatic behaviors is integrated in the brain." Previous research has shown that neural systems controlling sleep and feeding in mammals are interconnected: sleep deprivation promotes feeding, whereas starvation suppresses sleep, but little was known about the genes responsible for this interaction. Because the genes that make up Drosophila's internal clock have counterparts with similar functions in mammals, such as those controlling regulation of sleep and metabolism, the study of fruit fly genes can have implications for humans.
After initially screening around 2,000 genes, the researchers identified more than a dozen involved in the interaction between feeding and sleep. From this smaller group, they focused on the Clock and cycle genes, which play a role in both the fruit fly and mammalian circadian, or biological, clock.
To determine the impact of these two genes on the relationship between sleeping and feeding, the researchers examined fruit flies with and without the Clock and cycle genes under food deprivation conditions—the flies were given only a liquid gel containing no nutrients over a 24-hour period and the researchers monitored the flies' movement to determine resulting sleep behavior.
Their results showed a three-to-four-fold reduction in sleep in starved flies missing the Clock and cycle genes compared to flies possessing these genes. The findings therefore suggest that both Clock and cycle help the flies to regulate sleep when they are food deprived.
"This is a significant advance in how we approach behavioral genetics," said Alex Keene, PhD, a post-doctoral researcher in NYU's department of biology and the study's lead author. "We know that the brain is wired to engage in more than one behavior at a time, but less clear is how the brain chooses between these behaviors. These findings are transformative because they show that a gene can control sleep in a context-specific fashion. In the future, we will need to study animals in different environmental conditions in order to fully understand how the brain controls behavior. "
About the University of Massachusetts Medical School
The University of Massachusetts Medical School, one of the fastest growing academic health centers in the country, has built a reputation as a world-class research institution, consistently producing noteworthy advances in clinical and basic research. The Medical School attracts more than $240 million in research funding annually, 80 percent of which comes from federal funding sources. The mission of the Medical School is to advance the health and well-being of the people of the commonwealth and the world through pioneering education, research, public service and health care delivery with its clinical partner, UMass Memorial Health Care.
Jim Fessenden | EurekAlert!
The birth of a new protein
20.10.2017 | University of Arizona
Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
20.10.2017 | Information Technology
20.10.2017 | Materials Sciences
20.10.2017 | Interdisciplinary Research