Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Biological fingerprints improve diagnosis of dementia

Differentiating between the various forms of dementia is crucial for initiating appropriate treatment. Researchers at the Sahlgrenska Academy have discovered that the underlying diseases leave different "fingerprints" in the cerebrospinal fluid, paving the way for more reliable diagnoses.

The two most common forms of dementia are Alzheimer's disease and vascular dementia. The latter is caused by reduced circulation in the small blood vessels of the brain, which can be picked up in brain scans as small infarcts – strokes – or widespread changes in the white matter. The problem is that this small vessel disease presents very similarly to Alzheimer's disease, making it difficult in practice to distinguish between the two.

Biochemical fingerprints in CSF
Because the different diseases are treated differently, it is important to be able to make the correct diagnosis. Researcher Maria Bjerke from the Sahlgrenska Academy at the University of Gothenburg has shown in her thesis that the different forms of dementia are detectable as biochemical changes in the cerebrospinal fluid (CSF) long before any clinical symptoms emerge. The results are significant for how the most common age-related cognitive disorders are diagnosed.
Step towards better treatment
"As the CSF is in direct contact with the brain, its molecular composition can be expected to reflect the brain's metabolism," Bjerke explains. "Examining the molecular fingerprints in the CSF enables us to determine whether or not there is an ongoing pathological process".

"Mapping the biochemical differences between the various forms of dementia will help us to understand what caused the disease, which in turn will determine how the disease should be treated."
The possibility of differentiating between patients with mild cognitive disorders due to small vessel disease and patients with Alzheimer's needs to be given much greater attention, Bjerke believes, not least with a view to designing and implementing detailed treatment studies.

About dementia
Dementia is not a disease but a diagnosis for a series of symptoms that can be caused by a variety of illnesses and injuries. Two diseases account for around 90% of all cases of dementia: Alzheimer's (60-70% of cases) and vascular dementia (20-30%). More than 20,000 people in Sweden are diagnosed with dementia every year. Most of them are elderly, and around one in five people over the age of 80 is affected.

The thesis Cerebrospinal fluid biomarkers for differentiating between Alzheimer’s disease and vascular dementia was successfully defended on 9 June 2011. 

For further information, please contact: 
Maria Bjerke

Tel: +46 (0)31 343 2410

Mobile: +46 (0)706 530 260

Helena Aaberg | idw
Further information:

Further reports about: CSF blood vessel molecular fingerprint spinal fluid vascular dementia

More articles from Life Sciences:

nachricht When fat cells change their colour
28.10.2016 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht Aquaculture: Clear Water Thanks to Cork
28.10.2016 | Technologie Lizenz-Büro (TLB) der Baden-Württembergischen Hochschulen GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel light sources made of 2D materials

Physicists from the University of Würzburg have designed a light source that emits photon pairs. Two-photon sources are particularly well suited for tap-proof data encryption. The experiment's key ingredients: a semiconductor crystal and some sticky tape.

So-called monolayers are at the heart of the research activities. These "super materials" (as the prestigious science magazine "Nature" puts it) have been...

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Prototype device for measuring graphene-based electromagnetic radiation created

28.10.2016 | Power and Electrical Engineering

Gamma ray camera offers new view on ultra-high energy electrons in plasma

28.10.2016 | Physics and Astronomy

When fat cells change their colour

28.10.2016 | Life Sciences

More VideoLinks >>>