Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Biochemists Discover New Mechanism in Ribosome Formation

02.11.2012
Hitching a ride into the nucleus: Protein controls synchronised transport of ribosome factors

A new mechanism in the formation of ribosomes has been discovered by researchers from the Heidelberg University Biochemistry Center. In an interdisciplinary approach, the Heidelberg scientists, along with colleagues from Switzerland and Japan, describe a heretofore uncharacterised protein that plays a specific role in ribosome assembly in eukaryotes, organisms whose cells contain a cell nucleus.

This protein makes sure that specific factors required for ribosome synthesis are transported together, like hitchhikers, into the nucleus to the site of assembly. The results of this research were published in “Science”.

Ribosomes, the protein factories of the cell, are macromolecular complexes of ribonucleic acids (RNA) and ribosomal proteins (r-proteins) that are organised in a highly complicated three-dimensional nanostructure. Correct synthesis of ribosomes is critical for the division of all cells and is a process that follows strict rules.

In eukaryotes, new ribosomes are formed predominantly in the cell nucleus. Therefore, the r-proteins needed for ribosome formation must travel from the cytoplasm of the cell to a site in the nucleus where the ribosomes are assembled. Until recently it was not clear whether r-proteins that have a similar function and form functional clusters on the ribosome structure are also co-transported into the nucleus.

The researchers have now found a protein that coordinates the co-transport of certain r-proteins in functional clusters into the cell nucleus. This factor is called Symportin1, for synchronised import. “Symportin1 synchronises the import of both the Rpl5 and Rpl11 r-proteins into the cell nucleus and supports their integration into the growing ribosome structure”, explains Prof. Dr. Irmgard Sinning of the Heidelberg University Biochemistry Center (BZH). “It employs a familiar logistical concept from every day life, like picking up a hitchhiker or sharing a taxi with someone headed for the same destination”, says Dr. Gert Bange of the BZH, lead author of the study together with Dr. Dieter Kressler (now of Fribourg University).

The researchers from Heidelberg University and the University of Fribourg (Switzerland) collaborated closely with colleagues from Osaka University in Japan on the research. “The combination of different methods ranging from traditional cell biology to new biophysical approaches was crucial in developing the detailed picture of this previously unknown biological mechanism”, emphasises Prof. Dr. Ed Hurt, also of the BZH. The study took advantage of the Biochemistry Center’s crystallisation platform and the research received support from the Cluster of Excellence “CellNetworks” of Heidelberg University.

Original publication:
D. Kressler, G. Bange, Y. Ogawa, G. Stjepanovic, B. Bradatsch, D. Pratte, S. Amlacher, D. Strauß, Y. Yoneda, J. Kata-hira, I. Sinning, E. Hurt: Synchronizing Nuclear Import of Ribosomal Proteins with Ribosome Assembly, Science (2 November 2012), Vol. 338 no. 6107, 666-671, doi: 10.1126/science.1226960
Contact:
Prof. Dr. Irmgard Sinning / Prof. Dr. Ed Hurt
Heidelberg University Biochemistry Center
Phone: +49 (0)6221 54-4781, -4173
Irmi.sinning@bzh.uni-heidelberg.de
ed.hurt@bzh.uni-heidelberg.de
Communications and Marketing
Press Office
phone: +49 6221 54-2311
presse@rektorat.uni-heidelberg.de

Marietta Fuhrmann-Koch | idw
Further information:
http://www.uni-heidelberg.de

More articles from Life Sciences:

nachricht Rice study decodes genetic circuitry for bacterial spore formation
24.05.2016 | Rice University

nachricht How Neural Circuits Implement Natural Vision
24.05.2016 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Atomic precision: technologies for the next-but-one generation of microchips

In the Beyond EUV project, the Fraunhofer Institutes for Laser Technology ILT in Aachen and for Applied Optics and Precision Engineering IOF in Jena are developing key technologies for the manufacture of a new generation of microchips using EUV radiation at a wavelength of 6.7 nm. The resulting structures are barely thicker than single atoms, and they make it possible to produce extremely integrated circuits for such items as wearables or mind-controlled prosthetic limbs.

In 1965 Gordon Moore formulated the law that came to be named after him, which states that the complexity of integrated circuits doubles every one to two...

Im Focus: Researchers demonstrate size quantization of Dirac fermions in graphene

Characterization of high-quality material reveals important details relevant to next generation nanoelectronic devices

Quantum mechanics is the field of physics governing the behavior of things on atomic scales, where things work very differently from our everyday world.

Im Focus: Graphene: A quantum of current

When current comes in discrete packages: Viennese scientists unravel the quantum properties of the carbon material graphene

In 2010 the Nobel Prize in physics was awarded for the discovery of the exceptional material graphene, which consists of a single layer of carbon atoms...

Im Focus: Transparent - Flexible - Printable: Key technologies for tomorrow’s displays

The trend-forward world of display technology relies on innovative materials and novel approaches to steadily advance the visual experience, for example through higher pixel densities, better contrast, larger formats or user-friendler design. Fraunhofer ISC’s newly developed materials for optics and electronics now broaden the application potential of next generation displays. Learn about lower cost-effective wet-chemical printing procedures and the new materials at the Fraunhofer ISC booth # 1021 in North Hall D during the SID International Symposium on Information Display held from 22 to 27 May 2016 at San Francisco’s Moscone Center.

Economical processing

Im Focus: Trojan horses for hospital bugs

Staphylococcus aureus usually is a formidable bacterial pathogen. Sometimes, however, weakened forms are found in the blood of patients. Researchers of the University of Würzburg have now identified one mutation responsible for that phenomenon.

Staphylococcus aureus is a bacterium that is frequently found on the human skin and in the nose where it usually behaves inconspicuously. However, once inside...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Networking 4.0: International Laser Technology Congress AKL’16 Shows New Ways of Cooperations

24.05.2016 | Event News

Challenges of rural labor markets

20.05.2016 | Event News

International expert meeting “Health Business Connect” in France

19.05.2016 | Event News

 
Latest News

Rutgers scientists help create world's largest coral gene database

24.05.2016 | Earth Sciences

New technique controls autonomous vehicles on a dirt track

24.05.2016 | Information Technology

Programmable materials find strength in molecular repetition

24.05.2016 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>