The paper was published in Science, May 2008; 320: 677 – 681 and is the result of a collaboration between scientists at the Université Libre de Bruxelles, Belgium, and the University of Aarhus, Denmark.
A Biacore 3000 was used to examine binding parameters and properties of the parasite haptoglobin-hemoglobin (Hp-Hb) receptor TbHpHbR and its human functional analog CD163. The analysis showed that TbHpHbR binds the haptoglobin related protein-hemoglobin complex (Hpr-Hb) as well as Hp-Hb, unlike human CD163, suggesting that the parasite receptor is unable to discriminate between Hpr and Hp.
“The fact that the parasite actively uses a component of the host (hemoglobin) as a way to protect itself against the defenses of the host is an interesting facet of the biology of parasites. We discovered that the two subspecies of T. brucei that can infect humans both possess TbHpHpR,” said Dr. Etienne Pays, Université Libre de Bruxelles. “As the receptor shows equal affinity for the human-specific Hpr-Hb complex and the Hp-Hb complex, in contrast to the analogous human receptor CD163 which cannot bind Hpr-Hb, we deduce that TbHpHbR is a parasite-specific entry site for Hpr-Hb. Thus, the HprHb complex could be coupled to toxins and used as a novel drug against the parasite, targeting only the parasite and not the host.”
Dr. Søren Moestrup, University of Aarhus, commented: “Our next step is to contribute to the development of these new conjugate drugs, using the receptor as an entry point into the parasite. The assay using a Biacore system, developed during this investigation, will be essential for assessing binding of drug candidates to the receptor.”
Katie Odgaard | alfa
Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute
Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy