Dr. Shi directs the Neuroimmunology Laboratory and Flow Cytometry Core Facility at Barrow. One of his research interests is natural killer (NK) cells, a type of immune cell that destroys tissue that has been infected by pathogens and malignant cells. While recent research has shed more light on the role of NK cells in other parts of the body, Dr. Shi's research is unveiling important discoveries about how NK cells work in the CNS.
In multiple sclerosis, the body's immune system attacks myelin, a protective sheath surrounding nerve cells in the brain and spinal cord. By studying a pre-clinical model of multiple sclerosis, the Barrow research revealed that enriching an affected area with NK cells improved disease symptoms, while blocking NK cells to the CNS made symptoms worse. The research indicates that NK cells – especially those that originate in the CNS, as opposed to NK cells from peripheral organs – play a critical role in controlling the magnitude of CNS inflammation and immune response.
"These studies provide novel insight into the biology of NK cells and might lead to the design of NK cell-based approaches for intervention in inflammatory and autoimmune disorders of the central nervous system," says Dr. Shi. "Our findings have important implications for understanding the efficacy of some drugs currently used in CNS diseases such as multiple sclerosis."
About Barrow: Barrow Neurological Institute of St. Joseph's Hospital and Medical Center in Phoenix, Arizona, is internationally recognized as a leader in neurological research and patient care and is consistently voted as among the Top 10 hospitals for neurology and neurology in the United States. Barrow treats patients with a wide range of neurological conditions, including brain and spinal tumors, cerebrovascular conditions, and neuromuscular disorders. Barrow's clinicians and researchers are devoted to providing excellent patient care and finding better ways to treat neurological disorders.
Lynne Reaves | EurekAlert!
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The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
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With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
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An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
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Transistors based on carbon nanostructures: what sounds like a futuristic dream could be reality in just a few years' time. An international research team working with Empa has now succeeded in producing nanotransistors from graphene ribbons that are only a few atoms wide, as reported in the current issue of the trade journal "Nature Communications."
Graphene ribbons that are only a few atoms wide, so-called graphene nanoribbons, have special electrical properties that make them promising candidates for the...
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