In the closed form of RfaH (right), the C-terminal domain (CTD, blue) and the N-terminal domain (NTD, green) are close to each other. The alpha-helical CTD masks the area of the NTD which binds to the RNA polymerase. Binding to a specific piece of DNA results in domain separation (left) which in turn leads to the complete refolding of the CTD. In this state, the NTD can bind RNA polymerase and the CTD can bind ribosomal protein S10. RfaH is thus a regulatory component of the transcription of DNA into RNA.
Image: Dr. Stefan Knauer, University of Bayreuth; free for publication only when reference is included.
"Never before has such a fundamental structural change been observed for proteins", Prof. Paul Rösch notes. "This result is spectacular as we were able to simultaneously elucidate the structural transition and its functional consequences for central cellular processes in bacteria." RfaH's ability to change its structure enables regulation of the translation of bacterial genetic information into proteins (gene expression).Regulatory functions of the domains in gene expression
Christian Wißler | Universität Bayreuth
Further reports about: > Bio-Macromolecules > CTD > DNA > NTD > RNA > RNA polymerase > RfaH > Translation > amino acid > bacterial pathogens > bacterial protein > building block > cellular process > genetic information > magnetic resonance > magnetic resonance spectroscopy > molecular process > molecular structure > three-dimensional structure > transcription
Fine organic particles in the atmosphere are more often solid glass beads than liquid oil droplets
21.04.2017 | Max-Planck-Institut für Chemie
Study overturns seminal research about the developing nervous system
21.04.2017 | University of California - Los Angeles Health Sciences
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...
Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.
A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
21.04.2017 | Physics and Astronomy
21.04.2017 | Health and Medicine
21.04.2017 | Physics and Astronomy