Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Backstabbing bacteria: A new treatment for infection?

06.09.2010
Selfish bacterial cells that act in their own interests and do not cooperate with their infection-causing colleagues can actually reduce the severity of infection.

The selfish behaviour of these uncooperative bacteria could be exploited to treat antibiotic-resistant infections, according to research being presented at the Society for General Microbiology's autumn meeting today.

Bacteria work together by using a well-studied communication system called Quorum Sensing (QS). During infection, bacteria talk to each other using QS to coordinate the release of toxins.

Researchers at the University of Nottingham have discovered that in Staphylococcus aureus infections, bacteria defective in QS can benefit from 'opting out' of toxin production. By doing so, they can invest more energy in reproducing – whilst taking advantage of the nutrient-rich infection that is maintained by their neighbours.

By looking after themselves in this way, QS-deficient bacteria are quickly able to outnumber other bacteria that are busy producing toxins. As a result the overall severity of infection is reduced as fewer toxins are produced. "This opens up the interesting possibility of using these uncooperative bacteria to treat infection," said Mr Eric Pollitt who is presenting the study.

The group tested the theory by introducing S. aureus into waxworms that subsequently developed infections. "We found that the QS-deficient bacteria could not only outgrow normal bacteria in the same population, but that they could also invade other cooperating populations to reduce the severity of infection," explained Mr Pollitt. "This means that we could potentially isolate QS-deficient bacteria and use them to treat clinical S. aureus infections."

New approaches for the treatment of S. aureus infections are desperately needed as many strains of the bacterium, such as Meticillin-resistant Staphylococcus aureus (MRSA), are resistant to antibiotics. "Importantly, as any treatment involving QS-deficient bacteria would not be based on antibiotics, it could complement current treatments for S. aureus infections," said Mr Pollitt.

Using bacteria to treat bacterial infections is a potentially useful yet paradoxical approach. "It's an interesting concept of 'fighting like with like'," suggested Mr Pollitt. "This work also highlights that the interactions between bacteria during an infection can be just as important as the interactions between the bacteria and the host."

Laura Udakis | EurekAlert!
Further information:
http://www.sgm.ac.uk

More articles from Life Sciences:

nachricht Bolstering fat cells offers potential new leukemia treatment
17.10.2017 | McMaster University

nachricht Ocean atmosphere rife with microbes
17.10.2017 | King Abdullah University of Science & Technology (KAUST)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Ocean atmosphere rife with microbes

17.10.2017 | Life Sciences

Neutrons observe vitamin B6-dependent enzyme activity useful for drug development

17.10.2017 | Life Sciences

NASA finds newly formed tropical storm lan over open waters

17.10.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>