The study, published in the November 2008 issue of the Journal of Allergy and Clinical Immunology, is the first to focus on the links between antibody responses to cockroach and mouse proteins and respiratory and allergic symptoms in such a young age group.
"These findings increase our understanding of the relationship between immune responses to indoor allergens and the development of asthma and allergies in very young children," said lead author of the study, Kathleen Donohue, MD, fellow in Allergy and Immunology at Columbia University College of Physicians and Surgeons. The study found evidence that the likelihood of developing wheeze, hay fever, and eczema in preschool urban children was significantly increased among the children who were exposed to antibodies of both cockroach and mouse allergens.
This study is part of a broader multi-year research project launched in 1998 by CCCEH that examines the health effects of exposure of pregnant women and babies to indoor and outdoor air pollutants, pesticides, and allergens. The Center's prior research findings have shown that exposure to multiple environmental pollutants is associated with an increase in risk for asthma symptoms among children. These latest findings contribute to a further understanding of how the environment impacts child health.
"Our findings have significant public health implications," said Rachel L. Miller, MD, Irving Assistant Professor of Medicine and Environmental Health at NewYork –Presbyterian Hospital/Columbia University Medical Center; director, Asthma Project; associate director and lead physician scientist, DISCOVER Initiative, Mailman School of Public Health's CCCEH; and senior investigator on the study. "These are valuable findings given the high prevalence of asthma in New York City and elsewhere. They highlight the importance of reducing exposure to cockroach and mouse allergens at a very early age for susceptible children."
The researchers suggest that interventions directed towards cockroach and mouse allergen reduction may also have long-term benefit to inner city children who are susceptible to these exposures.
The study was co-authored by researchers from the Division of Pulmonary, Allergy and Critical Care Medicine at Columbia University College of Physicians and Surgeons and the Columbia Center for Children's Environmental Health. Other investigators on the study include Umaima Al-alem, PhD, Matthew Perzanowski, PhD, Ginger Chew, ScD, Alina Johnson, Adnan Divjan, Elizabeth Kelvin, PhD, Lori Hoepner, MPH, and Frederica Perera, DrPH, director of CCCEH.
The investigators controlled for exposure to tobacco smoke and maternal history of asthma, both of which may influence the likelihood of developing asthma or allergies. A prospective follow-up of this birth cohort will help determine whether the development of anti-cockroach, anti-mouse immunoglobulin (Ig) E by age three is associated with impaired lung function and/or persistent asthma, according to the researchers.
Stephanie Berger | EurekAlert!
Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University
Transfecting cells gently – the LZH presents a GNOME prototype at the Labvolution 2017
25.04.2017 | Laser Zentrum Hannover e.V.
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
25.04.2017 | Physics and Astronomy
25.04.2017 | Materials Sciences
25.04.2017 | Life Sciences