The study, published in the November 2008 issue of the Journal of Allergy and Clinical Immunology, is the first to focus on the links between antibody responses to cockroach and mouse proteins and respiratory and allergic symptoms in such a young age group.
"These findings increase our understanding of the relationship between immune responses to indoor allergens and the development of asthma and allergies in very young children," said lead author of the study, Kathleen Donohue, MD, fellow in Allergy and Immunology at Columbia University College of Physicians and Surgeons. The study found evidence that the likelihood of developing wheeze, hay fever, and eczema in preschool urban children was significantly increased among the children who were exposed to antibodies of both cockroach and mouse allergens.
This study is part of a broader multi-year research project launched in 1998 by CCCEH that examines the health effects of exposure of pregnant women and babies to indoor and outdoor air pollutants, pesticides, and allergens. The Center's prior research findings have shown that exposure to multiple environmental pollutants is associated with an increase in risk for asthma symptoms among children. These latest findings contribute to a further understanding of how the environment impacts child health.
"Our findings have significant public health implications," said Rachel L. Miller, MD, Irving Assistant Professor of Medicine and Environmental Health at NewYork –Presbyterian Hospital/Columbia University Medical Center; director, Asthma Project; associate director and lead physician scientist, DISCOVER Initiative, Mailman School of Public Health's CCCEH; and senior investigator on the study. "These are valuable findings given the high prevalence of asthma in New York City and elsewhere. They highlight the importance of reducing exposure to cockroach and mouse allergens at a very early age for susceptible children."
The researchers suggest that interventions directed towards cockroach and mouse allergen reduction may also have long-term benefit to inner city children who are susceptible to these exposures.
The study was co-authored by researchers from the Division of Pulmonary, Allergy and Critical Care Medicine at Columbia University College of Physicians and Surgeons and the Columbia Center for Children's Environmental Health. Other investigators on the study include Umaima Al-alem, PhD, Matthew Perzanowski, PhD, Ginger Chew, ScD, Alina Johnson, Adnan Divjan, Elizabeth Kelvin, PhD, Lori Hoepner, MPH, and Frederica Perera, DrPH, director of CCCEH.
The investigators controlled for exposure to tobacco smoke and maternal history of asthma, both of which may influence the likelihood of developing asthma or allergies. A prospective follow-up of this birth cohort will help determine whether the development of anti-cockroach, anti-mouse immunoglobulin (Ig) E by age three is associated with impaired lung function and/or persistent asthma, according to the researchers.
Stephanie Berger | EurekAlert!
Rainbow colors reveal cell history: Uncovering β-cell heterogeneity
22.09.2017 | DFG-Forschungszentrum für Regenerative Therapien TU Dresden
The pyrenoid is a carbon-fixing liquid droplet
22.09.2017 | Max-Planck-Institut für Biochemie
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
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