Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Ancient humans were mixing it up

06.09.2011
Anatomically modern humans interbred with more archaic hominin forms even before they migrated out of Africa, a UA-led team of researchers has found.

It is now widely accepted that the species Homo sapiens originated in Africa and eventually spread throughout the world. But did those early humans interbreed with more ancestral forms of the genus Homo, for example Homo erectus, the "upright walking man," Homo habilis, – the "tool-using man" or Homo neanderthalensis, the first artists of cave-painting fame?

Direct studies of ancient DNA from Neanderthal bones suggest interbreeding did occur after anatomically modern humans had migrated from their evolutionary cradle in Africa to the cooler climates of Eurasia, but what had happened in Africa remained a mystery – until now.

In a paper published in the Proceedings of the National Academy of Sciences, or PNAS, a team led by Michael Hammer, an associate professor and research scientist with the UA's Arizona Research Labs, provides evidence that anatomically modern humans were not so unique that they remained separate.

"We found evidence for hybridization between modern humans and archaic forms in Africa. It looks like our lineage has always exchanged genes with their more morphologically diverged neighbors," said Hammer, who also holds appointments in the UA's department ofecology and evolutionary biology, the school of anthropology, the BIO5 Institute and the Arizona Cancer Center.

Hammer added that recent advances in molecular biology have made it possible to extract DNA from fossils tens of thousands of years old and compare it to that of modern counterparts.

However, "We don't have fossil DNA from Africa to compare with ours," he said. "Neanderthals lived in colder climates, but the climate in more tropical areas make it very tough for DNA to survive that long, so recovering usable samples from fossil specimens is extremely difficult if not impossible."

"Our work is different from the research that led to the breakthroughs in Neanderthal genetics," he explained. "We couldn't look directly for ancient DNA that is 40,000 years old and make a direct comparison."

To get past this hindrance, Hammer's team followed a computational and statistical approach.

"Instead, we looked at DNA from modern humans belonging to African populations and searched for unusual regions in the genome."

Because nobody knows the DNA sequences of those now extinct archaic forms, Hammer's team first had to figure out what features of modern DNA might represent fragments that were brought in from archaic forms.

"What we do know is that the sequences of those forms, even the Neanderthals, are not that different from modern humans," he said. "They have certain characteristics that make them different from modern DNA."

The researchers used simulations to predict what ancient DNA sequences would look like had they survived within the DNA of our own cells.

"You could say we simulated interbreeding and exchange of genetic material in silico," Hammer said. "We can simulate a model of hybridization between anatomically modern humans and some archaic form. In that sense, we simulate history so that we can see what we would expect the pattern to look like if it did occur."

According to Hammer, the first signs of anatomically modern features appeared about 200,000 years ago.

First, the team sequenced vast regions of human genomes from samples taken from six different populations living in Africa today and tried to match up their sequences with what they expected those sequences to look like in archaic forms. The researchers focused on non-coding regions of the genome, stretches of DNA that do not contain genes, which serve as the blueprints for proteins.

"Then we asked ourselves what does the general pattern of variation look like in the DNA that we sequenced in those African populations, and we started to look at regions that looked unusual," Hammer said. "We discovered three different genetic regions fit the criteria for being archaic DNA still present in the genomes of sub-Saharan Africans. Interestingly, this signature was strongest in populations from central Africa."

The scientists applied several criteria to tag a DNA sequence as archaic. For example, if a DNA sequence differed radically from the ones found in a modern population, it was likely to be ancient in origin. Another telltale sign is how far it extends along a chromosome. If an unusual piece is found to stretch a long portion of a chromosome, it is an indication of being brought into the population relatively recently.

"We are talking about something that happened between 20,000 and 60,000 years ago – not that long ago in the scheme of things," Hammer said. "If interbreeding occurs, it's going to bring in a whole chromosome, and over time, recombination events will chop the chromosome down to smaller pieces. And those pieces will now be found as short, unusual fragments. By looking at how long they are we can get an estimate of how far back the interbreeding event happened."

Hammer said that even though the archaic DNA sequences account for only two or three percent of what is found in modern humans, that doesn't mean the interbreeding wasn't more extensive.

"It could be that this represents what's left of a more extensive archaic genetic content today. Many of the sequences we looked for would be expected to be lost over time. Unless they provide a distinct evolutionary advantage, there is nothing keeping them in the population and they drift out."

In a next step, Hammer's team wants to look for ancient DNA regions that conferred some selective advantage to the anatomically modern humans once they acquired them.

"We think there were probably thousands of interbreeding events," Hammer said. "It happened relatively extensively and regularly."

"Anatomically modern humans were not so unique that they remained separate," he added. "They have always exchanged genes with their more morphologically diverged neighbors. This is quite common in nature, and it turns out we're not so unusual after all."

The paper, Genetic Evidence for Archaic Admixture in Africa, was co-authored by August Woerner from the UA's ARL Division of Biotechnology, Fernando Mendez from the UA's department of ecology and evolutionary biology, Joseph Watkins from the UA's Mathematics Department and Jeffrey Wall from the Institute for Human Genetics at the University of California San Francisco.

Daniel Stolte | EurekAlert!
Further information:
http://www.arizona.edu

More articles from Life Sciences:

nachricht A novel socio-ecological approach helps identifying suitable wolf habitats
17.02.2017 | Universität Zürich

nachricht New, ultra-flexible probes form reliable, scar-free integration with the brain
16.02.2017 | University of Texas at Austin

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Switched-on DNA

20.02.2017 | Materials Sciences

Second cause of hidden hearing loss identified

20.02.2017 | Health and Medicine

Prospect for more effective treatment of nerve pain

20.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>