Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Anchoring proteins influence glucose metabolism and insulin release

03.09.2012
Scientists from the United States and Sweden have discovered a new control point that could be important as a drug target for the treatment of diabetes and other metabolic diseases.

A-kinase anchoring proteins or AKAPs are known to influence the spatial distribution of kinases within the cell, crucial enzymes that control important molecular events related to the regulation of glucose levels in the blood.


A-kinase anchoring protein: a potential new drug target for diabetes

Image: John D Scott & EMBO

In a new study published in The EMBO Journal, the team of researchers led by Simon Hinke and John Scott reveal for the first time that AKAPs influence the levels of glucose in the body by coordinating the spatial positioning of phosphatases, naturally occurring enzymes that counteract the effects of kinase enzymes.

“Our discovery that anchored enzymes contribute to the regulation of cellular events that underlie diabetes may help us to move more rapidly toward new therapies to control this increasingly prevalent metabolic disease,” commented John Scott, Edwin G. Krebs–Hilma Speights Professor of Pharmacology at the University of Washington School of Medicine, Seattle and an investigator of the Howard Hughes Medical Institute. “The observation that AKAP 150 functions by coordinating phosphatase activity in the cell reveals a new role for these anchoring proteins in the control of glucose metabolism and related metabolic disorders. It also suggests that new drugs that interfere with the role of anchoring proteins are possible therapeutic interventions to treat chronic diseases such as diabetes.”

The researchers used imaging techniques as well as genetic modification of isolated insulin-secreting cells and whole mice to investigate the impact of anchoring proteins on glucose metabolism and insulin release. Mice that lacked the gene for the AKAP150 anchoring protein produced less insulin from beta cells in the islets of Langerhans. However, they coped better with limited amounts of hormone due to increased sensitivity to insulin in the target tissues (skeletal muscle). The scientists showed that these effects are due to a seven-amino-acid sequence in the anchor protein that directly interacts with the surface of the phosphatase enzyme.
The release of insulin is the main way in which the levels of glucose are controlled in the body. If it is possible to develop drugs that target the region where anchoring proteins specifically interact with phosphatase enzymes it is feasible that insulin sensitivity could be improved in selected tissues such as skeletal muscle. This would represent a valuable new molecular control point that might offer clinical benefits for diabetics, individuals with other metabolic disorders and patients who are being treated with immunosuppressive drugs following organ transplantation.

Anchored phosphatases modulate glucose homeostasis

Simon A. Hinke, Manuel F Navedo, Allison Ulman, Jennifer L Whiting, Patrick J Nygren, Geng Tian, Antonio J Jimenez-Caliani, Lorene K Langeberg, Vincenzo Cirulli, Anders Tengholm, Mark L Dell’Acqua, L Fernando Santana, John D Scott

Read the paper:
10.1038/emboj.2012.244

Further information on The EMBO Journal is available at http://www.nature.com/emboj

Media Contacts
Barry Whyte
Head | Public Relations and Communications

Yvonne Kaul
Communications Offer
Tel: +49 6221 8891 108/111
communications@embo.org

About EMBO
EMBO stands for excellence in the life sciences. The organization enables the best science by supporting talented researchers, stimulating scientific exchange and advancing policies for a world-class European research environment.

EMBO is an organization of 1500 leading life scientist members that fosters new generations of researchers to produce world-class scientific results. EMBO helps young scientists to advance their research, promote their international reputations and ensure their mobility. Courses, workshops, conferences and scientific journals disseminate the latest research and offer training in cutting-edge techniques to maintain high standards of excellence in research practice. EMBO helps to shape science and research policy by seeking input and feedback from our community and by following closely the trends in science in Europe.

Yvonne Kaul | EMBO
Further information:
http://www.embo.org
http://www.embo.org/news-a-media-centre/press-releases/anchoring-proteins-influence-glucose-metabolism-and-insulin-release.html
http://www.nature.com/emboj/journal/vaop/ncurrent/full/emboj2012244a.html

More articles from Life Sciences:

nachricht 'Y' a protein unicorn might matter in glaucoma
23.10.2017 | Georgia Institute of Technology

nachricht Microfluidics probe 'cholesterol' of the oil industry
23.10.2017 | Rice University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Salmonella as a tumour medication

HZI researchers developed a bacterial strain that can be used in cancer therapy

Salmonellae are dangerous pathogens that enter the body via contaminated food and can cause severe infections. But these bacteria are also known to target...

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Symposium on Driving Simulation

23.10.2017 | Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

 
Latest News

Microfluidics probe 'cholesterol' of the oil industry

23.10.2017 | Life Sciences

Gamma rays will reach beyond the limits of light

23.10.2017 | Physics and Astronomy

The end of pneumonia? New vaccine offers hope

23.10.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>