Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

American researchers identify genetic ‘trigger’ for stem cell differentiation

07.12.2009
A gene which is essential for stem cells’ capabilities to become any cell type has been identified by researchers at the Hebrew University of Jerusalem and the University of California, San Francisco.

The discovery represents a further step in the ever-expanding field of understanding the ways in which stem cells develop into specific cells, a necessary prelude towards the use of stem cell therapy as a means to reverse the consequences of disease and disability.

The identification of the gene, known as Chd1, was made by Dr. Eran Meshorer of the Alexander Silberman Institute of Life Sciences at the Hebrew University and Adi Alajem, a Ph.D. student in his lab, along with the UCSF researchers.

Embryonic stem (ES) cells, which are primary cells derived from the early developing embryo, are capable of giving rise, according to their environment and conditions, to any cell type -- a trait known as pluripotency. It was assumed that the ES cells have a relatively high degree of open chromatin, which is thought to enable their pluripotency, a theory which awaited proof.

Chromatin, which is found in all cells, is composed of DNA and its surrounding proteins and can be found in one of two conformations: closed chromatin (heterochromatin) – when the genetic material is packed in a way that prevents the expression of the genes -- and open chromatin (euchromatin) – when chromatin is accessible to the gene expression machinery. Different cells display varying degrees of open and closed chromatin as a function of the genes required for their function.

In their current study, which was published recently in Nature magazine, the researchers from the Hebrew University and UCSF showed, using mouse ES cells, that Chd1 regulates open chromatin in ES cells. The open chromatin conformation, maintained by Chd1, enabled the expression of a wide variety of genes, leading to proper differentiation into all types of specific cells. Depletion of Chd1 in embryonic stem cells led to formation of heterochromatin (closed chromatin) and prevented the ability of the cells to generate all types of tissues.

The study, therefore, showed a proven link between open chromatin in ES cells and their pluripotency – an important finding on the road to the implementation of stem cell applications in future medical treatment.

Jerry Barach | Hebrew University
Further information:
http://www.huji.ac.il

More articles from Life Sciences:

nachricht Tag it EASI – a new method for accurate protein analysis
19.06.2018 | Max-Planck-Institut für Biochemie

nachricht How to track and trace a protein: Nanosensors monitor intracellular deliveries
19.06.2018 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

Im Focus: Photoexcited graphene puzzle solved

A boost for graphene-based light detectors

Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Carbon nanotube optics provide optical-based quantum cryptography and quantum computing

19.06.2018 | Physics and Astronomy

How to track and trace a protein: Nanosensors monitor intracellular deliveries

19.06.2018 | Life Sciences

New material for splitting water

19.06.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>