Dr Mason explains: ‘In neurodegenerative diseases such as Alzheimer's or Parkinson's, aggregation (or clumping) of proteins into toxic fibrils (or chains) is considered to be the key pathogenic event.
However, no therapeutic agents currently exist to control this process. In particular, two proteins known as ß-amyloid and a-synuclein aggregate into fibrils, forming amyloid plaques and Lewy bodies that are characteristic of these diseases. A problem arises, however, in antagonist development; in recent years it has become established that small soluble (protofibrillar) forms of amyloid are the neurotoxic species, and that larger fibrils rather serve as reservoirs for these smaller protofibrils.’
‘Unfortunately, peptides and drugs designed to prevent amyloid have until recently been concerned with removing these larger fibrillar deposits. If compounds designed to breakdown amyloid are only partially effective then the balance will be shifted in the direction of smaller protofibrillar forms, rendering the amyloid more toxic in the process. We will use our expertise in the amyloid, protein-protein interaction, and library screening and design fields to combat this.’
This grant application follows on from Dr Mason's previous experience in the field. There are currently 700,000 people living with dementia in the UK, this will rise to more than a million in less than 20 years. At present, dementia costs the UK around £17 billion each year. Development of drugs capable of slowing or stopping the onset of Alzheimer’s or Parkinson's disease would improve the lives of millions of sufferers worldwide.
Victoria Bartholomew | alfa
Multi-institutional collaboration uncovers how molecular machines assemble
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02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
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In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
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The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
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Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
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The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
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