Dr Mason explains: ‘In neurodegenerative diseases such as Alzheimer's or Parkinson's, aggregation (or clumping) of proteins into toxic fibrils (or chains) is considered to be the key pathogenic event.
However, no therapeutic agents currently exist to control this process. In particular, two proteins known as ß-amyloid and a-synuclein aggregate into fibrils, forming amyloid plaques and Lewy bodies that are characteristic of these diseases. A problem arises, however, in antagonist development; in recent years it has become established that small soluble (protofibrillar) forms of amyloid are the neurotoxic species, and that larger fibrils rather serve as reservoirs for these smaller protofibrils.’
‘Unfortunately, peptides and drugs designed to prevent amyloid have until recently been concerned with removing these larger fibrillar deposits. If compounds designed to breakdown amyloid are only partially effective then the balance will be shifted in the direction of smaller protofibrillar forms, rendering the amyloid more toxic in the process. We will use our expertise in the amyloid, protein-protein interaction, and library screening and design fields to combat this.’
This grant application follows on from Dr Mason's previous experience in the field. There are currently 700,000 people living with dementia in the UK, this will rise to more than a million in less than 20 years. At present, dementia costs the UK around £17 billion each year. Development of drugs capable of slowing or stopping the onset of Alzheimer’s or Parkinson's disease would improve the lives of millions of sufferers worldwide.
Victoria Bartholomew | alfa
One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie
The dark side of cichlid fish: from cannibal to caregiver
20.04.2018 | Veterinärmedizinische Universität Wien
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
20.04.2018 | Life Sciences
20.04.2018 | Life Sciences
19.04.2018 | Materials Sciences