Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Allergy treatment may cause new allergy

14.12.2010
Allergic contact dermatitis from aluminium has previously been considered very unusual. However, there are now reports of pruritic nodules and aluminium allergy arising after vaccinations or treatments for allergies. Researcher Eva Netterlid has studied the problem in a thesis recently defended at Lund University in Sweden.

‘Pruritic nodules’ are small lumps under the skin that cause itching and which, according to some studies, can remain for several years. A study of whooping cough vaccinations in Gothenburg a few years ago showed that almost one per cent of the children developed pruritic nodules in the area of the vaccination. Three out of four of the children who had a reaction with nodules also developed an allergy to aluminium.

“This was completely unexpected. Aluminium has been used as an adjuvant, intensifier, in vaccines for over 70 years with only a small number of reports of pruritic nodules and allergic contact dermatitis”, says Eva Netterlid. Her research has been carried out at the Occupational and Environmental Dermatology Unit in Malmö.

There are a number of possible explanations as to why aluminium allergy has become more common. There is new technology for identifying the allergy, the type of aluminium compounds used in vaccines and other treatments may have changed, and the number of vaccinations has increased with the increase in international travel.

Eva Netterlid only found a very small number of pruritic nodules in a study of diphtheria vaccinations of Swedish 10-year-olds. She then went on to study hyposensitisation, a treatment in which gradually higher doses of an allergenic substance are given to patients who are allergic to pollen, mites, etc. to habituate them to the substance.

This treatment also uses aluminium as an intensifier. The follow-up in this case showed a higher number of reactions. Of 37 children treated, allergic contact dermatitis from aluminium was seen in 8 children and pruritic nodules in 13 children. The 24 children with allergies who were included in the study but who were not given the treatment had neither pruritic nodules nor aluminium allergy.

Another study was of hyposensitisation of children and adults with allergic respiratory diseases. It was found that almost four per cent of the subjects had allergic contact dermatitis from aluminium. There were individuals with aluminium allergy in both the treated and the untreated group, and the allergy could therefore not be conclusively linked to the treatment. However, examination of the patients’ arms before and one year after the treatment showed that the number of people with nodules had increased significantly, and the proportion who had pruritic nodules had also increased.

Eva Netterlid and her colleagues hope to be able to continue with their research in the area. One important issue is whether different aluminium compounds produce different outcomes; another is whether those who have had a positive result in the test for aluminium allergy also have clinical symptoms when exposed to drugs and cosmetics containing aluminium.

Eva Netterlid can be contacted by telephone, +46 46 18 85 35, +46 708 988535, or by email, eva.netterlid@med.lu.se.

Pressofficer Ingela Björck; ingela.bjorck@rektor.lu.se; +46-46 222 7646

Ingela Björck | idw
Further information:
http://www.vr.se

More articles from Life Sciences:

nachricht Modern genetic sequencing tools give clearer picture of how corals are related
17.08.2017 | University of Washington

nachricht The irresistible fragrance of dying vinegar flies
16.08.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Gold shines through properties of nano biosensors

17.08.2017 | Physics and Astronomy

Greenland ice flow likely to speed up: New data assert glaciers move over sediment, which gets more slippery as it gets wetter

17.08.2017 | Earth Sciences

Mars 2020 mission to use smart methods to seek signs of past life

17.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>