Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Allergy treatment may cause new allergy

14.12.2010
Allergic contact dermatitis from aluminium has previously been considered very unusual. However, there are now reports of pruritic nodules and aluminium allergy arising after vaccinations or treatments for allergies. Researcher Eva Netterlid has studied the problem in a thesis recently defended at Lund University in Sweden.

‘Pruritic nodules’ are small lumps under the skin that cause itching and which, according to some studies, can remain for several years. A study of whooping cough vaccinations in Gothenburg a few years ago showed that almost one per cent of the children developed pruritic nodules in the area of the vaccination. Three out of four of the children who had a reaction with nodules also developed an allergy to aluminium.

“This was completely unexpected. Aluminium has been used as an adjuvant, intensifier, in vaccines for over 70 years with only a small number of reports of pruritic nodules and allergic contact dermatitis”, says Eva Netterlid. Her research has been carried out at the Occupational and Environmental Dermatology Unit in Malmö.

There are a number of possible explanations as to why aluminium allergy has become more common. There is new technology for identifying the allergy, the type of aluminium compounds used in vaccines and other treatments may have changed, and the number of vaccinations has increased with the increase in international travel.

Eva Netterlid only found a very small number of pruritic nodules in a study of diphtheria vaccinations of Swedish 10-year-olds. She then went on to study hyposensitisation, a treatment in which gradually higher doses of an allergenic substance are given to patients who are allergic to pollen, mites, etc. to habituate them to the substance.

This treatment also uses aluminium as an intensifier. The follow-up in this case showed a higher number of reactions. Of 37 children treated, allergic contact dermatitis from aluminium was seen in 8 children and pruritic nodules in 13 children. The 24 children with allergies who were included in the study but who were not given the treatment had neither pruritic nodules nor aluminium allergy.

Another study was of hyposensitisation of children and adults with allergic respiratory diseases. It was found that almost four per cent of the subjects had allergic contact dermatitis from aluminium. There were individuals with aluminium allergy in both the treated and the untreated group, and the allergy could therefore not be conclusively linked to the treatment. However, examination of the patients’ arms before and one year after the treatment showed that the number of people with nodules had increased significantly, and the proportion who had pruritic nodules had also increased.

Eva Netterlid and her colleagues hope to be able to continue with their research in the area. One important issue is whether different aluminium compounds produce different outcomes; another is whether those who have had a positive result in the test for aluminium allergy also have clinical symptoms when exposed to drugs and cosmetics containing aluminium.

Eva Netterlid can be contacted by telephone, +46 46 18 85 35, +46 708 988535, or by email, eva.netterlid@med.lu.se.

Pressofficer Ingela Björck; ingela.bjorck@rektor.lu.se; +46-46 222 7646

Ingela Björck | idw
Further information:
http://www.vr.se

More articles from Life Sciences:

nachricht Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

NASA examines Peru's deadly rainfall

24.03.2017 | Earth Sciences

What does congenital Zika syndrome look like?

24.03.2017 | Health and Medicine

Steep rise of the Bernese Alps

24.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>